APOBEC4
Template:Short description An Error has occurred retrieving Wikidata item for infobox C->U-editing enzyme APOBEC-4, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4, is a protein that in humans is encoded by the APOBEC4 gene. It is primarily expressed in testis and found in mammals, chicken, but not fishes.[1][2]
Function
This gene encodes a member of the AID / APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection.[2]
A recent study on APOBEC4 (A4) revealed an interesting finding that A4 enhanced the replication of HIV-1 through boosting promoter activity, it also increased the expression of other relevant promoter mediated enhanced protein expression. Biochemical analysis of A4 showed the lack of cytidine deaminase activity on single stranded DNA and it binds DNA rather weak.[3]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Rogozin IB, Basu MK, Jordan IK, Pavlov YI, Koonin EV (September 2005). "APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis". Cell Cycle. 4 (9): 1281–5. doi:10.4161/cc.4.9.1994. PMID 16082223.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: apolipoprotein B mRNA editing enzyme".
- ^ Page Module:Citation/CS1/styles.css has no content.Marino D, Perković M, Hain A, Jaguva Vasudevan AA, Hofmann H, Hanschmann KM, Mühlebach MD, Schumann GG, König R, Cichutek K, Häussinger D, Münk C (2016). "APOBEC4 Enhances the Replication of HIV-1". PLOS ONE. 11 (6) e0155422. Bibcode:2016PLoSO..1155422M. doi:10.1371/journal.pone.0155422. PMC 4889046. PMID 27249646.
External links
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Prochnow C, Bransteitter R, Chen XS (October 2009). "APOBEC deaminases-mutases with defensive roles for immunity". Science in China Series C: Life Sciences. 52 (10): 893–902. doi:10.1007/s11427-009-0133-1. PMID 19911124. S2CID 22054803.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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