DGKA
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Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene.[1][2][3]
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[3]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Hart TC, Champagne C, Zhou J, Van Dyke TE (Jun 1994). "Assignment of the gene for diacylglycerol kinase (DAGK) to human chromosome 12". Mamm Genome. 5 (2): 123–4. doi:10.1007/BF00292343. PMID 8180475. S2CID 305119.
- ^ Page Module:Citation/CS1/styles.css has no content.Hart TC, Zhou J, Champagne C, Van Dyke TE, Rao PN, Pettenati MJ (Dec 1994). "Assignment of the human diacylglycerol kinase gene (DAGK) to 12q13.3 using fluorescence in situ hybridization analysis". Genomics. 22 (1): 246–7. doi:10.1006/geno.1994.1376. PMID 7959783.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: DGKA diacylglycerol kinase, alpha 80kDa".
Further reading
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[1]*Page Module:Citation/CS1/styles.css has no content.Topham MK, Prescott SM (1999). "Mammalian diacylglycerol kinases, a family of lipid kinases with signaling functions". J. Biol. Chem. 274 (17): 11447–50. doi:10.1074/jbc.274.17.11447. PMID 10206945.
- Page Module:Citation/CS1/styles.css has no content.Schaap D, de Widt J, van der Wal J, Vandekerckhove J, Van Damme J, Gussow D, Ploegh HL, Van Blitterswijk WJ, Van Der Bend RL (1991). "Purification, cDNA-cloning and expression of human diacylglycerol kinase". FEBS Lett. 275 (1–2): 151–8. doi:10.1016/0014-5793(90)81461-V. PMID 2175712. S2CID 45452518.
- Page Module:Citation/CS1/styles.css has no content.Flores I, Casaseca T, Martinez-A C, Kanoh H, Merida I (1996). "Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation". J. Biol. Chem. 271 (17): 10334–40. doi:10.1074/jbc.271.17.10334. hdl:10261/378836. PMID 8626603.
- Page Module:Citation/CS1/styles.css has no content.Jones DR, Pettitt TR, Sanjuán MA, Mérida I, Wakelam MJ (1999). "Interleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerol". J. Biol. Chem. 274 (24): 16846–52. doi:10.1074/jbc.274.24.16846. PMID 10358029.
- Page Module:Citation/CS1/styles.css has no content.Sanjuán MA, Jones DR, Izquierdo M, Mérida I (2001). "Role of Diacylglycerol Kinase α in the Attenuation of Receptor Signaling". J. Cell Biol. 153 (1): 207–20. doi:10.1083/jcb.153.1.207. PMC 2185527. PMID 11285286.
- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Sanjuán MA, Pradet-Balade B, Jones DR, Martínez-a C, Stone JC, Garcia-Sanz JA, Mérida I (2003). "T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation". J. Immunol. 170 (6): 2877–83. doi:10.4049/jimmunol.170.6.2877. PMID 12626538.
- Page Module:Citation/CS1/styles.css has no content.Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
- Page Module:Citation/CS1/styles.css has no content.Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Page Module:Citation/CS1/styles.css has no content.Gronert K, Kantarci A, Levy BD, Clish CB, Odparlik S, Hasturk H, Badwey JA, Colgan SP, Van Dyke TE (2004). "A molecular defect in intracellular lipid signaling in human neutrophils in localized aggressive periodontal tissue damage". J. Immunol. 172 (3): 1856–61. doi:10.4049/jimmunol.172.3.1856. PMC 4318492. PMID 14734770.
- Page Module:Citation/CS1/styles.css has no content.Verrier E, Wang L, Wadham C, Albanese N, Hahn C, Gamble JR, Chatterjee VK, Vadas MA, Xia P (2004). "PPARgamma agonists ameliorate endothelial cell activation via inhibition of diacylglycerol-protein kinase C signaling pathway: role of diacylglycerol kinase". Circ. Res. 94 (11): 1515–22. doi:10.1161/01.RES.0000130527.92537.06. PMID 15117825. S2CID 25057646.
- Page Module:Citation/CS1/styles.css has no content.Baldanzi G, Mitola S, Cutrupi S, Filigheddu N, Van Blitterswijk WJ, Sinigaglia F, Bussolino F, Graziani A (2004). "Activation of diacylglycerol kinase alpha is required for VEGF-induced angiogenic signaling in vitro". Oncogene. 23 (28): 4828–38. doi:10.1038/sj.onc.1207633. hdl:11379/21460. PMID 15122338.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Page Module:Citation/CS1/styles.css has no content.Alonso R, Rodríguez MC, Pindado J, Merino E, Mérida I, Izquierdo M (2005). "Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes". J. Biol. Chem. 280 (31): 28439–50. doi:10.1074/jbc.M501112200. hdl:10261/158459. PMID 15870081.
- Page Module:Citation/CS1/styles.css has no content.Bacchiocchi R, Baldanzi G, Carbonari D, Capomagi C, Colombo E, Van Blitterswijk WJ, Graziani A, Fazioli F (2005). "Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase". Blood. 106 (6): 2175–82. doi:10.1182/blood-2005-01-0316. PMID 15928040.
- Page Module:Citation/CS1/styles.css has no content.Yanagisawa K, Yasuda S, Kai M, Imai S, Yamada K, Yamashita T, Jimbow K, Kanoh H, Sakane F (2007). "Diacylglycerol kinase alpha suppresses tumor necrosis factor-alpha-induced apoptosis of human melanoma cells through NF-kappaB activation". Biochim. Biophys. Acta. 1771 (4): 462–74. doi:10.1016/j.bbalip.2006.12.008. PMID 17276726.
External links
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- ^ Page Module:Citation/CS1/styles.css has no content.Kovalenko A, Sanin A, Kosmas K, Zhang L, Wang J, Giannikou K, Probst CK, Hougard TR, Rue RW, Krymskaya VP, Asara JM, Lam HC, Kwiatkowski DJ, Henske EP, Filippakis H (2021). "Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex". Cancer Research. 81 (8): 2086–2100. doi:10.1158/0008-5472.CAN-20-2218. PMC 8137542. PMID 33593821.
