TOLLIP
From Wikipedia, the free encyclopedia
Template:Short description An Error has occurred retrieving Wikidata item for infobox Toll interacting protein, also known as TOLLIP, is an inhibitory adaptor protein that in humans is encoded by the TOLLIP gene.[1][2][3]
Function and regulation
It is an inhibitory adaptor protein within Toll-like receptors (TLR).[4] The TLR pathway is a part of the innate immune system that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response.
Tollip interacts with cellular and subcellular membrane compartments such as endosome and lysosome through its C2 domain binding with phosphoinositides.[5] By coordinating organelle communications, Tollip can contribute to the fusion of endo-lysosome and autophagosome. Mice with Tollip deletion exhibit elevated risks for inflammatory diseases such as atherosclerosis and neurodegeneration.[6]
Clinical significance
Polymorphisms in TLR genes have been implicated in various diseases like atopic dermatitis.[7] Recently, variations in the TOLLIP gene have been associated with tuberculosis and idiopathic pulmonary fibrosis.[8][9]
Interactions
TOLLIP has been shown to interact with TOM1,[10] TLR 2,[11] TLR 4[11] and IL1RAP.[3]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: TOLLIP toll interacting protein".
- ^ Page Module:Citation/CS1/styles.css has no content.Volpe F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K (December 1997). "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex". FEBS Letters. 419 (1): 41–44. Bibcode:1997FEBSL.419...41V. doi:10.1016/S0014-5793(97)01426-9. PMID 9426216. S2CID 39772937.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, et al. (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nature Cell Biology. 2 (6): 346–351. doi:10.1038/35014038. PMID 10854325. S2CID 32036101.
- ^ Page Module:Citation/CS1/styles.css has no content.Bulut Y, Faure E, Thomas L, Equils O, Arditi M (July 2001). "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling". Journal of Immunology. 167 (2): 987–994. doi:10.4049/jimmunol.167.2.987. PMID 11441107.
- ^ Page Module:Citation/CS1/styles.css has no content.Li T, Hu J, Li L (May 2004). "Characterization of Tollip protein upon Lipopolysaccharide challenge". Molecular Immunology. 41 (1): 85–92. doi:10.1016/j.molimm.2004.03.009. PMID 15140579.
- ^ Page Module:Citation/CS1/styles.css has no content.Kowalski EJ, Li L (May 2017). "Toll-Interacting Protein in Resolving and Non-Resolving Inflammation". Frontiers in Immunology. 8 (511): 511. doi:10.3389/fimmu.2017.00511. PMC 5418219. PMID 28529512.
- ^ Page Module:Citation/CS1/styles.css has no content.Schimming TT, Parwez Q, Petrasch-Parwez E, Nothnagel M, Epplen JT, Hoffjan S (March 2007). "Association of toll-interacting protein gene polymorphisms with atopic dermatitis". BMC Dermatology. 7: 3. doi:10.1186/1471-5945-7-3. PMC 1832210. PMID 17362526.
- ^ Page Module:Citation/CS1/styles.css has no content.Shah JA, Vary JC, Chau TT, Bang ND, Yen NT, Farrar JJ, et al. (August 2012). "Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis". Journal of Immunology. 189 (4): 1737–1746. doi:10.4049/jimmunol.1103541. PMC 3428135. PMID 22778396.
- ^ Page Module:Citation/CS1/styles.css has no content.Noth I, Zhang Y, Ma SF, Flores C, Barber M, Huang Y, et al. (June 2013). "Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study". The Lancet. Respiratory Medicine. 1 (4): 309–317. doi:10.1016/S2213-2600(13)70045-6. PMC 3894577. PMID 24429156.
- ^ Page Module:Citation/CS1/styles.css has no content.Yamakami M, Yoshimori T, Yokosawa H (December 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". The Journal of Biological Chemistry. 278 (52): 52865–52872. doi:10.1074/jbc.M306740200. PMID 14563850.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Zhang G, Ghosh S (March 2002). "Negative regulation of toll-like receptor-mediated signaling by Tollip". The Journal of Biological Chemistry. 277 (9): 7059–7065. doi:10.1074/jbc.M109537200. PMID 11751856.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Nilsen KH (May 1976). "Malignant lymphoma and rheumatic symptoms". The New Zealand Medical Journal. 83 (563): 320–322. PMID 1085432.
- Page Module:Citation/CS1/styles.css has no content.Volpe F, Clatworthy J, Kaptein A, Maschera B, Griffin AM, Ray K (December 1997). "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex". FEBS Letters. 419 (1): 41–44. Bibcode:1997FEBSL.419...41V. doi:10.1016/S0014-5793(97)01426-9. PMID 9426216. S2CID 39772937.
- Page Module:Citation/CS1/styles.css has no content.Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, et al. (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nature Cell Biology. 2 (6): 346–351. doi:10.1038/35014038. PMID 10854325. S2CID 32036101.
- Page Module:Citation/CS1/styles.css has no content.Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Page Module:Citation/CS1/styles.css has no content.Bulut Y, Faure E, Thomas L, Equils O, Arditi M (July 2001). "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling". Journal of Immunology. 167 (2): 987–994. doi:10.4049/jimmunol.167.2.987. PMID 11441107.
- Page Module:Citation/CS1/styles.css has no content.Zhang G, Ghosh S (March 2002). "Negative regulation of toll-like receptor-mediated signaling by Tollip". The Journal of Biological Chemistry. 277 (9): 7059–7065. doi:10.1074/jbc.M109537200. PMID 11751856.
- Page Module:Citation/CS1/styles.css has no content.Yamakami M, Yoshimori T, Yokosawa H (December 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". The Journal of Biological Chemistry. 278 (52): 52865–52872. doi:10.1074/jbc.M306740200. PMID 14563850.
- Page Module:Citation/CS1/styles.css has no content.Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K (June 2004). "Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes". The Journal of Biological Chemistry. 279 (23): 24435–24443. doi:10.1074/jbc.M400059200. PMID 15047686.
- Page Module:Citation/CS1/styles.css has no content.Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Page Module:Citation/CS1/styles.css has no content.Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Page Module:Citation/CS1/styles.css has no content.Ohnuma K, Yamochi T, Uchiyama M, Nishibashi K, Iwata S, Hosono O, et al. (September 2005). "CD26 mediates dissociation of Tollip and IRAK-1 from caveolin-1 and induces upregulation of CD86 on antigen-presenting cells". Molecular and Cellular Biology. 25 (17): 7743–7757. doi:10.1128/MCB.25.17.7743-7757.2005. PMC 1190283. PMID 16107720.
- Page Module:Citation/CS1/styles.css has no content.Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Page Module:Citation/CS1/styles.css has no content.Katoh Y, Imakagura H, Futatsumori M, Nakayama K (March 2006). "Recruitment of clathrin onto endosomes by the Tom1-Tollip complex". Biochemical and Biophysical Research Communications. 341 (1): 143–149. doi:10.1016/j.bbrc.2005.12.156. PMID 16412388.
- Page Module:Citation/CS1/styles.css has no content.Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, et al. (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
- Page Module:Citation/CS1/styles.css has no content.Brissoni B, Agostini L, Kropf M, Martinon F, Swoboda V, Lippens S, et al. (November 2006). "Intracellular trafficking of interleukin-1 receptor I requires Tollip". Current Biology. 16 (22): 2265–2270. Bibcode:2006CBio...16.2265B. doi:10.1016/j.cub.2006.09.062. PMID 17113392. S2CID 13938932.
Lua error in package.lua at line 80: module 'Module:Navbox/configuration' not found.
Lua error in package.lua at line 80: module 'Module:Navbox/configuration' not found.
