Risedronic acid

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Risedronic acid
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Clinical data
Trade namesActonel, Atelvia, Benet, others
AHFS/Drugs.comMonograph
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Pregnancy
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  • AU: B3
Routes of
administration		By mouth
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Legal status
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Pharmacokinetic data
Bioavailability0.63%
Protein binding~24%
MetabolismNone
Elimination half-life1.5 h
ExcretionKidney and fecal
Identifiers
  • (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonic acid
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Chemical and physical data
FormulaC7H11NO7P2
Molar mass283.113 g·mol−1
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  • OC(Cc1cccnc1)(P(=O)(O)O)P(=O)(O)O
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Risedronic acid, often used as its sodium salt risedronate sodium, is a bisphosphonate.[1] It slows down the cells which break down bone.[1] It's used to treat or prevent osteoporosis, and treat Paget's disease of bone.[1] It is taken by mouth.[1]

It was patented in 1984 and approved for medical use in 1998.[2]

Pharmacology

Relative potency[3]
Bisphosphonate Relative potency
Etidronate 1
Tiludronate 10
Pamidronate 100
Alendronate 100-500
Ibandronate 500-1000
Risedronate 1000
Zoledronate 5000

History

Risedronate, known as NE-58095 while under development, was discovered by scientists at the Cincinnati Miami Valley Laboratories and the Norwich Eaton Laboratories of Procter and Gamble. [4]

Society and culture

Brand names

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It is produced and marketed by Warner Chilcott, Sanofi-Aventis, and in Japan by Takeda under the trade names Actonel, Atelvia, and Benet. It is also available in a preparation that includes a calcium carbonate supplement, as Actonel with Calcium.

Controversies

In January 2006 P&G and its marketing partner Sanofi-Aventis filed a Lanham Act false claims lawsuit against rival drugmakers Roche and GlaxoSmithKline claiming false advertising about Boniva.[5] The manufacturers of Boniva, a rival bisphosphonate, were accused in the suit of causing a "serious public health risk" through misrepresentation of scientific findings. In a ruling on September 7, 2006, U.S. District Judge Paul A. Crotty rejected P&G's attempted injunction. P&G was criticized for attempting to "preserve its market share by denigrating Boniva". Judge Crotty wrote that "Roche was clearly entitled to respond with its own data, provided that the data was truthfully and accurately presented".[6]

In 2006, P&G faced controversy over its handling of clinical research involving risedronate (News Reports[7] and discussion).[8]

In common with other bisphosphonate drugs, risedronate appears to be associated with the rare side effect osteonecrosis of the jaw, often preceded by dental procedures inducing trauma to the bone.

References

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  1. ^ a b c d e Page Module:Citation/CS1/styles.css has no content."Actonel- risedronate sodium tablet, film coated". DailyMed. 1 November 2019. Retrieved 28 June 2022.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 523. ISBN 978-3-527-60749-5.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Tripathi KD (30 September 2013). Essentials of medical pharmacology (Seventh ed.). New Delhi: Jaypee Brothers Medical Publishers Ltd. ISBN 978-93-5025-937-5. OCLC 868299888.
  4. ^ Page Module:Citation/CS1/styles.css has no content.McClung MR, Ebetino FH (August 2020). "History of risedronate". Bone. 137 (115407) 115407. doi:10.1016/j.bone.2020.115407. ISSN 8756-3282. PMID 32387834. Retrieved April 25, 2025.
  5. ^ Page Module:Citation/CS1/styles.css has no content."P&G Press statement". Uk.pg.com. Archived from the original on 2011-09-29. Retrieved 2013-03-01.
  6. ^ Page Module:Citation/CS1/styles.css has no content."Boniva advertising 'not misleading' says US judge". Pharma Times. 8 September 2006.
  7. ^ Page Module:Citation/CS1/styles.css has no content."Actonel Case Media Reports". Scientific Misconduct Wiki. Archived from the original on 2 February 2009.
  8. ^ Page Module:Citation/CS1/styles.css has no content."Scientific Misconduct Blog". Scientific-misconduct.blogspot.com. Retrieved 2013-03-01.

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