Bone morphogenetic protein 10
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Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.[1][2]
BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins.[2] It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.
BMP10 has also emerged as a novel atrial specific biomarker used in cardiovascular research, especially in the field of atrial fibrillation (AF). Latest research has revealed strong associations between plasma concentration of BMP10 and the risk for ischemic stroke in patients with atrial fibrillation as well as with the risk of AF recurrence after ablation for AF.[3][4]
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, et al. (April 2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes and Immunity. 11 (3): 232–238. doi:10.1038/gene.2010.1. PMID 20237496. S2CID 11183658.
- Page Module:Citation/CS1/styles.css has no content.Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, et al. (April 2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–731. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
- Page Module:Citation/CS1/styles.css has no content.Mazerbourg S, Sangkuhl K, Luo CW, Sudo S, Klein C, Hsueh AJ (September 2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". The Journal of Biological Chemistry. 280 (37): 32122–32132. doi:10.1074/jbc.M504629200. PMID 16049014.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (October 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Page Module:Citation/CS1/styles.css has no content.Nakano N, Hori H, Abe M, Shibata H, Arimura T, Sasaoka T, et al. (December 2007). "Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy". American Journal of Physiology. Heart and Circulatory Physiology. 293 (6) H3396–403. doi:10.1152/ajpheart.00311.2007. PMID 17921333. S2CID 45084505.
- Page Module:Citation/CS1/styles.css has no content.Marroni F, Pfeufer A, Aulchenko YS, Franklin CS, Isaacs A, Pichler I, et al. (August 2009). "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project". Circulation. Cardiovascular Genetics. 2 (4): 322–328. doi:10.1161/CIRCGENETICS.108.833806. PMC 2760953. PMID 20031603.
- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.David L, Mallet C, Mazerbourg S, Feige JJ, Bailly S (March 2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood. 109 (5): 1953–1961. doi:10.1182/blood-2006-07-034124. PMID 17068149.
References
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- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: bone morphogenetic protein 10".
- ^ a b Page Module:Citation/CS1/styles.css has no content.Neuhaus H, Rosen V, Thies RS (February 1999). "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily". Mechanisms of Development. 80 (2): 181–184. doi:10.1016/S0925-4773(98)00221-4. PMID 10072785. S2CID 15626081.
- ^ Page Module:Citation/CS1/styles.css has no content.Hijazi Z, Benz AP, Lindbäck J, Alexander JH, Connolly SJ, Eikelboom JW, et al. (January 2023). "Bone morphogenetic protein 10: a novel risk marker of ischaemic stroke in patients with atrial fibrillation". European Heart Journal. 44 (3): 208–218. doi:10.1093/eurheartj/ehac632. PMC 9839419. PMID 36380569.
- ^ Page Module:Citation/CS1/styles.css has no content.Reyat JS, Chua W, Cardoso VR, Witten A, Kastner PM, Kabir SN, et al. (August 2020). "Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation". JCI Insight. 5 (16) e139179. doi:10.1172/jci.insight.139179. PMC 7455124. PMID 32814717.
External links
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