Caspase 10
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Template:Cs1 config Template:Short description An Error has occurred retrieving Wikidata item for infobox Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.[1]
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme.
That protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]
Interactions
Caspase 10 has been shown to interact with FADD,[3][4][5] CFLAR,[4][6][7] Caspase 8,[8][9][10] Fas receptor,[8][3][11] RYBP,[12] TNFRSF1A[8][3] and TNFRSF10B.[8][11]
See also
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES (October 1996). "In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains". Proc Natl Acad Sci USA. 93 (15): 7464–9. Bibcode:1996PNAS...93.7464F. doi:10.1073/pnas.93.15.7464. PMC 38767. PMID 8755496.
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- ^ a b Page Module:Citation/CS1/styles.css has no content.Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES (July 1997). "FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis". J. Biol. Chem. 272 (30). UNITED STATES: 18542–5. doi:10.1074/jbc.272.30.18542. ISSN 0021-9258. PMID 9228018.
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- ^ Page Module:Citation/CS1/styles.css has no content.Micheau O, Tschopp Jürg (July 2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes". Cell. 114 (2). United States: 181–90. Bibcode:2003Cell..114..181M. doi:10.1016/S0092-8674(03)00521-X. ISSN 0092-8674. PMID 12887920.
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- ^ Page Module:Citation/CS1/styles.css has no content.Zheng L, Schickling O, Peter M E, Lenardo M J (August 2001). "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". J. Biol. Chem. 276 (34). United States: 31945–52. doi:10.1074/jbc.M102799200. ISSN 0021-9258. PMID 11395500.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Cohen GM (1997). "Caspases: the executioners of apoptosis". Biochem. J. 326 (Pt 1): 1–16. doi:10.1042/bj3260001. PMC 1218630. PMID 9337844.
- Page Module:Citation/CS1/styles.css has no content.Clements GB, Klein G, Povey S (1975). "Production by EBV infection of an EBNA-positive subline from an EBNA-negative human lymphoma cell line without detectable EBV DNA". Int. J. Cancer. 16 (1): 125–33. doi:10.1002/ijc.2910160114. PMID 170210. S2CID 30408863.
- Page Module:Citation/CS1/styles.css has no content.Baumann K, de Rouffignac C, Roinel N, et al. (1975). "Renal phosphate transport: inhomogeneity of local proximal transport rates and sodium dependence". Pflügers Arch. 356 (4): 287–98. doi:10.1007/BF00580003. PMID 1171445. S2CID 259484.
- Page Module:Citation/CS1/styles.css has no content.DuBridge RB, Tang P, Hsia HC, et al. (1987). "Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system". Mol. Cell. Biol. 7 (1): 379–87. doi:10.1128/mcb.7.1.379. PMC 365079. PMID 3031469.
- Page Module:Citation/CS1/styles.css has no content.Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Page Module:Citation/CS1/styles.css has no content.Fernandes-Alnemri T, Takahashi A, Armstrong R, et al. (1996). "Mch3, a novel human apoptotic cysteine protease highly related to CPP32". Cancer Res. 55 (24): 6045–52. PMID 8521391.
- Page Module:Citation/CS1/styles.css has no content.Srinivasula SM, Ahmad M, Fernandes-Alnemri T, et al. (1997). "Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases". Proc. Natl. Acad. Sci. U.S.A. 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. doi:10.1073/pnas.93.25.14486. PMC 26159. PMID 8962078.
- Page Module:Citation/CS1/styles.css has no content.Vincenz C, Dixit VM (1997). "Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling". J. Biol. Chem. 272 (10): 6578–83. doi:10.1074/jbc.272.10.6578. PMID 9045686.
- Page Module:Citation/CS1/styles.css has no content.Bourquin JP, Stagljar I, Meier P, et al. (1997). "A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II". Nucleic Acids Res. 25 (11): 2055–61. doi:10.1093/nar/25.11.2055. PMC 146702. PMID 9153302.
- Page Module:Citation/CS1/styles.css has no content.Shu HB, Halpin DR, Goeddel DV (1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847.
- Page Module:Citation/CS1/styles.css has no content.Srinivasula SM, Ahmad M, Ottilie S, et al. (1997). "FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis". J. Biol. Chem. 272 (30): 18542–5. doi:10.1074/jbc.272.30.18542. PMID 9228018.
- Page Module:Citation/CS1/styles.css has no content.Goltsev YV, Kovalenko AV, Arnold E, et al. (1997). "CASH, a novel caspase homologue with death effector domains". J. Biol. Chem. 272 (32): 19641–4. doi:10.1074/jbc.272.32.19641. PMID 9289491.
- Page Module:Citation/CS1/styles.css has no content.MacFarlane M, Ahmad M, Srinivasula SM, et al. (1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J. Biol. Chem. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. hdl:2381/25106. PMID 9325248.
- Page Module:Citation/CS1/styles.css has no content.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Page Module:Citation/CS1/styles.css has no content.Hu S, Snipas SJ, Vincenz C, et al. (1998). "Caspase-14 is a novel developmentally regulated protease". J. Biol. Chem. 273 (45): 29648–53. doi:10.1074/jbc.273.45.29648. PMID 9792675.
- Page Module:Citation/CS1/styles.css has no content.Ng PW, Porter AG, Jänicke RU (1999). "Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10". J. Biol. Chem. 274 (15): 10301–8. doi:10.1074/jbc.274.15.10301. PMID 10187817.
- Page Module:Citation/CS1/styles.css has no content.Wang J, Zheng L, Lobito A, et al. (1999). "Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II". Cell. 98 (1): 47–58. doi:10.1016/S0092-8674(00)80605-4. PMID 10412980.
- Page Module:Citation/CS1/styles.css has no content.Satoh S, Hijikata M, Handa H, Shimotohno K (1999). "Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha". Biochem. J. 342 (Pt 1): 65–70. doi:10.1042/0264-6021:3420065. PMC 1220437. PMID 10432301.
External links
- GeneReviews/NCBI/NIH/UW entry on Autoimmune Lymphoproliferative Syndrome
- The MEROPS online database for peptidases and their inhibitors: C14.011
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