Ergotamine/caffeine

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Ergotamine/caffeine
Combination of
Ergotaminevasoconstrictor, neurotransmitter agonist and antagonist
Caffeinevasoconstrictor, phosphodiesterase inhibitor
Clinical data
Trade namesCafergot, Migergot, others
AHFS/Drugs.comMultum Consumer Information
MedlinePlusa601048
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Pregnancy
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  • AU: C
  • Contraindicated
Routes of
administration		By mouth, rectal
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Identifiers
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Ergotamine/caffeine, sold under the brand name Cafergot among others, is a fixed-dose combination medication used for the treatment of migraine. It contains ergotamine, as the tartrate, an alpha adrenergic blocking agent; and caffeine, a cranial vasoconstrictor.[3]

Ergotamine/caffeine is available as a generic medication.

Medical uses

Ergotamine/caffeine is indicated as therapy to abort or prevent vascular headache.[1][2]

Mechanism of action

Ergotamine binds to 5-HT1B and 5-HT1D receptors.[4] This along with binding to other serotonergic and dopaminergic receptors is their presumed mechanism of action in treating migraine.[4][5]

Adverse effects

Because the vasoconstrictive effects of ergotamine and caffeine are not selective for the brain, adverse effects due to systemic vasoconstriction can occur. Cold feet or hands, angina pectoris, myocardial infarction,[6] or dizziness are some examples.

It has also been shown to be associated with mitral valve stenosis. [7]

References

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  1. ^ a b Page Module:Citation/CS1/styles.css has no content."Cafergot- ergotamine tartrate and caffeine tablet, film coated". DailyMed. U.S. National Library of Medicine. Archived from the original on 16 January 2014.
  2. ^ a b Page Module:Citation/CS1/styles.css has no content."Migergot- ergotamine tartrate and caffeine suppository". DailyMed. 29 November 2022. Retrieved 18 May 2024.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Diener HC, Jansen JP, Reches A, Pascual J, Pitei D, Steiner TJ (2002). "Efficacy, tolerability and safety of oral eletriptan and ergotamine plus caffeine (Cafergot) in the acute treatment of migraine: a multicentre, randomised, double-blind, placebo-controlled comparison". European Neurology. 47 (2): 99–107. doi:10.1159/000047960. PMID 11844898. S2CID 72629130.
  4. ^ a b Page Module:Citation/CS1/styles.css has no content."Acute treatment of migraine in adults". UpToDate. Wolters Kluwer. 15 January 2018. Retrieved 27 March 2018.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Fanciullacci M, Granchi G, Sicuteri F (November 1976). "Ergotamine and methysergide as serotonin partial agonists in migraine". Headache. 16 (5): 226–231. doi:10.1111/j.1526-4610.1976.hed1605226.x. PMID 977328. S2CID 45861917.
  6. ^ Page Module:Citation/CS1/styles.css has no content.Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Michael K, Welch A, eds. (2006). The Headaches (3rd ed.). Lippincott Williams and Wilkins. p. 463. ISBN 978-0781754002.
  7. ^ Page Module:Citation/CS1/styles.css has no content.Austin SM, el-Hayek A, Comianos M, Tamulonis DJ (October 1993). "Mitral valve disease associated with long-term ergotamine use". Southern Medical Journal. 86 (10): 1179–1181. doi:10.1097/00007611-199310000-00024. PMID 8211344.

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