Delta-like 1
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Template:Short description An Error has occurred retrieving Wikidata item for infobox Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.[1]
Function
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.[1]
Interactions
Delta-like 1 has been shown to interact with NOTCH2.[2][3][4]
References
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- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: DLL1 delta-like 1 (Drosophila)".
- ^ Page Module:Citation/CS1/styles.css has no content.Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.
- ^ Page Module:Citation/CS1/styles.css has no content.Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302. S2CID 16544864.
- ^ Page Module:Citation/CS1/styles.css has no content.Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/mcb.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Watt FM (2002). "The stem cell compartment in human interfollicular epidermis". J. Dermatol. Sci. 28 (3): 173–80. doi:10.1016/S0923-1811(02)00003-8. PMID 11912004.
- Page Module:Citation/CS1/styles.css has no content.Lewis AK, Frantz GD, Carpenter DA, de Sauvage FJ, Gao WQ (1999). "Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear". Mech. Dev. 78 (1–2): 159–63. doi:10.1016/S0925-4773(98)00165-8. PMID 9858718. S2CID 9675950.
- Page Module:Citation/CS1/styles.css has no content.Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1999). "Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation". Dev. Biol. 204 (2): 420–31. doi:10.1006/dbio.1998.9092. PMID 9882480.
- Page Module:Citation/CS1/styles.css has no content.Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256.
- Page Module:Citation/CS1/styles.css has no content.Beckers J, Clark A, Wünsch K, Hrabé De Angelis M, Gossler A (1999). "Expression of the mouse Delta1 gene during organogenesis and fetal development". Mech. Dev. 84 (1–2): 165–8. doi:10.1016/S0925-4773(99)00065-9. PMID 10473134. S2CID 15047523.
- Page Module:Citation/CS1/styles.css has no content.Morrison A, Hodgetts C, Gossler A, Hrabé de Angelis M, Lewis J (1999). "Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear". Mech. Dev. 84 (1–2): 169–72. doi:10.1016/S0925-4773(99)00066-0. PMID 10473135. S2CID 17955906.
- Page Module:Citation/CS1/styles.css has no content.Han W, Ye Q, Moore MA (2000). "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells". Blood. 95 (5): 1616–25. doi:10.1182/blood.V95.5.1616.005k31_1616_1625. PMID 10688816.
- Page Module:Citation/CS1/styles.css has no content.Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
- Page Module:Citation/CS1/styles.css has no content.Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.
- Page Module:Citation/CS1/styles.css has no content.Jaleco AC, Neves H, Hooijberg E, Gameiro P, Clode N, Haury M, Henrique D, Parreira L (2001). "Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation". J. Exp. Med. 194 (7): 991–1002. doi:10.1084/jem.194.7.991. PMC 2193482. PMID 11581320.
- Page Module:Citation/CS1/styles.css has no content.Shimizu K, Chiba S, Saito T, Takahashi T, Kumano K, Hamada Y, Hirai H (2002). "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain". EMBO J. 21 (3): 294–302. doi:10.1093/emboj/21.3.294. PMC 125840. PMID 11823422.
- Page Module:Citation/CS1/styles.css has no content.Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.
- Page Module:Citation/CS1/styles.css has no content.Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.
- Page Module:Citation/CS1/styles.css has no content.Ohishi K, Varnum-Finney B, Bernstein ID (2002). "Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells". J. Clin. Invest. 110 (8): 1165–74. doi:10.1172/JCI16167. PMC 150801. PMID 12393852.
- Page Module:Citation/CS1/styles.css has no content.Karlström H, Beatus P, Dannaeus K, Chapman G, Lendahl U, Lundkvist J (2003). "A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 17119–24. doi:10.1073/pnas.252624099. PMC 139279. PMID 12482954.
- Page Module:Citation/CS1/styles.css has no content.Tohda S, Murata-Ohsawa M, Sakano S, Nara N (2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". Int. J. Oncol. 22 (5): 1073–9. doi:10.3892/ijo.22.5.1073. PMID 12684674.
- Page Module:Citation/CS1/styles.css has no content.Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, Logeat F (2003). "The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7638–43. Bibcode:2003PNAS..100.7638S. doi:10.1073/pnas.1230693100. PMC 164639. PMID 12794186.
- Page Module:Citation/CS1/styles.css has no content.LaVoie MJ, Selkoe DJ (2003). "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". J. Biol. Chem. 278 (36): 34427–37. doi:10.1074/jbc.M302659200. PMID 12826675.
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