EFEMP2
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(Redirected from FBLN4)
Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene.[1][2][3]
A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. EFEMP2 (also known as fibulin-4) contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is widely expressed in a range of adult and fetal tissues.[3]
Interactions
EFEMP2 has been shown to interact with P53.[4]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Giltay R, Timpl R, Kostka G (Feb 2000). "Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4". Matrix Biol. 18 (5): 469–80. doi:10.1016/S0945-053X(99)00038-4. PMID 10601734.
- ^ Page Module:Citation/CS1/styles.css has no content.Katsanis N, Venable S, Smith JR, Lupski JR (Sep 2000). "Isolation of a paralog of the Doyne honeycomb retinal dystrophy gene from the multiple retinopathy critical region on 11q13". Hum Genet. 106 (1): 66–72. doi:10.1007/s004390051011 (inactive 12 July 2025). PMID 10982184.
{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link) - ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: EFEMP2 EGF-containing fibulin-like extracellular matrix protein 2".
- ^ Page Module:Citation/CS1/styles.css has no content.Gallagher WM, Argentini M, Sierra V, Bracco L, Debussche L, Conseiller E (Jun 1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene. 18 (24): 3608–16. doi:10.1038/sj.onc.1202937. ISSN 0950-9232. PMID 10380882.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Gallagher WM, Argentini M, Sierra V, et al. (1999). "MBP1: a novel mutant p53-specific protein partner with oncogenic properties". Oncogene. 18 (24): 3608–16. doi:10.1038/sj.onc.1202937. PMID 10380882.
- Page Module:Citation/CS1/styles.css has no content.Gallagher WM, Greene LM, Ryan MP, et al. (2001). "Human fibulin-4: analysis of its biosynthetic processing and mRNA expression in normal and tumour tissues". FEBS Lett. 489 (1): 59–66. Bibcode:2001FEBSL.489...59G. doi:10.1016/S0014-5793(00)02389-9. PMID 11231014. S2CID 24614042.
- Page Module:Citation/CS1/styles.css has no content.Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Page Module:Citation/CS1/styles.css has no content.Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Page Module:Citation/CS1/styles.css has no content.Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Page Module:Citation/CS1/styles.css has no content.Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Page Module:Citation/CS1/styles.css has no content.Xiang Y, Sekine T, Nakamura H, et al. (2006). "Fibulin-4 is a target of autoimmunity predominantly in patients with osteoarthritis". J. Immunol. 176 (5): 3196–204. doi:10.4049/jimmunol.176.5.3196. PMID 16493080.
- Page Module:Citation/CS1/styles.css has no content.Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi:10.1038/nature04632. PMID 16554811.
- Page Module:Citation/CS1/styles.css has no content.Hucthagowder V, Sausgruber N, Kim KH, et al. (2006). "Fibulin-4: a novel gene for an autosomal recessive cutis laxa syndrome". Am. J. Hum. Genet. 78 (6): 1075–80. doi:10.1086/504304. PMC 1474103. PMID 16685658.
- Page Module:Citation/CS1/styles.css has no content.El-Hallous E, Sasaki T, Hubmacher D, et al. (2007). "Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin". J. Biol. Chem. 282 (12): 8935–46. doi:10.1074/jbc.M608204200. PMID 17255108.
External links
