Fluorodopa (18F)
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| Clinical data | |
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| Trade names | Fluorodopa F18 |
| Other names | 6-fluoro-L-DOPA, FDOPA |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
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| Routes of administration | Intravenous |
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| Chemical and physical data | |
| Formula | C9H10FNO4 |
| Molar mass | 215.180 g·mol−1 |
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Fluorodopa (18F), also known as FDOPA, is a fluorinated form of L-DOPA primarily synthesized as its fluorine-18 isotopologue for use as a radiotracer in positron emission tomography (PET).[2]
The most common side effects are injection site pain.[1]
Medical uses
Fluorodopa (18F) is indicated for use in positron emission tomography (PET) to visualize dopaminergic nerve terminals in the striatum for the evaluation of adults with suspected Parkinsonian syndromes.[1]
History
In October 2019, Fluorodopa (18F) was approved in the United States for the visual detection of certain nerve cells in adults with suspected Parkinsonian syndromes.[3][4]
The US Food and Drug Administration approved Fluorodopa F 18 based on evidence from one clinical trial of 56 participants with suspected Parkinsonian syndromes.[3] The trial was conducted at one clinical site in the United States.[3]
References
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- ^ a b c Page Module:Citation/CS1/styles.css has no content."Fluorodopa F18 injection". DailyMed. 12 October 2019. Retrieved 26 April 2020.
- ^ Page Module:Citation/CS1/styles.css has no content.Deng WP, Wong KA, Kirk KL (June 2002). "Convenient syntheses of 2-, 5- and 6-fluoro- and 2,6-difluoro-L-DOPA". Tetrahedron: Asymmetry. 13 (11): 1135–1140. doi:10.1016/S0957-4166(02)00321-X.
- ^ a b c Page Module:Citation/CS1/styles.css has no content."Drug Trials Snapshots: Fluorodopa F 18". U.S. Food and Drug Administration (FDA). 27 November 2019. Archived from the original on 27 November 2019. Retrieved 27 November 2019.
This article incorporates text from this source, which is in the public domain.
- ^ Page Module:Citation/CS1/styles.css has no content."Drug Approval Package: Fluorodopa F18". U.S. Food and Drug Administration (FDA). 20 November 2019. Archived from the original on 27 November 2019. Retrieved 26 November 2019.
This article incorporates text from this source, which is in the public domain.
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