Importin subunit alpha-1
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Template:Cs1 config Template:Short description An Error has occurred retrieving Wikidata item for infobox Importin subunit alpha-1 is a protein that in humans is encoded by the KPNA2 gene.[1][2]
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import are members of the alpha importin family of karyopherins such as importin subunit alpha-1. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination[3]
Interactions
Karyopherin alpha 2 has been shown to interact with:
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References
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- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)".
- ^ Page Module:Citation/CS1/styles.css has no content.Lin CY, Huang PH, Liao WL, Cheng HJ, Huang CF, Kuo JC, Patton WA, Massenburg D, Moss J, Lee FJ (Dec 2000). "ARL4, an ARF-like protein that is developmentally regulated and localized to nuclei and nucleoli". The Journal of Biological Chemistry. 275 (48): 37815–23. doi:10.1074/jbc.M002470200. PMID 10980193.
- ^ Page Module:Citation/CS1/styles.css has no content.Perez-Villar JJ, O'Day K, Hewgill DH, Nadler SG, Kanner SB (Oct 2001). "Nuclear localization of the tyrosine kinase Itk and interaction of its SH3 domain with karyopherin alpha (Rch1alpha)". International Immunology. 13 (10): 1265–74. doi:10.1093/intimm/13.10.1265. PMID 11581171.
- ^ Page Module:Citation/CS1/styles.css has no content.Nagoshi E, Yoneda Y (Apr 2001). "Dimerization of sterol regulatory element-binding protein 2 via the helix-loop-helix-leucine zipper domain is a prerequisite for its nuclear localization mediated by importin beta". Molecular and Cellular Biology. 21 (8): 2779–89. doi:10.1128/MCB.21.8.2779-2789.2001. PMC 86908. PMID 11283257.
- ^ Page Module:Citation/CS1/styles.css has no content.Köhler M, Speck C, Christiansen M, Bischoff FR, Prehn S, Haller H, Görlich D, Hartmann E (Nov 1999). "Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import". Molecular and Cellular Biology. 19 (11): 7782–91. doi:10.1128/mcb.19.11.7782. PMC 84838. PMID 10523667.
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- ^ Page Module:Citation/CS1/styles.css has no content.Seki T, Tada S, Katada T, Enomoto T (May 1997). "Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL". Biochemical and Biophysical Research Communications. 234 (1): 48–53. doi:10.1006/bbrc.1997.6535. PMID 9168958.
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Further reading
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- Page Module:Citation/CS1/styles.css has no content.Kino T, Pavlakis GN (Apr 2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA and Cell Biology. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
- Page Module:Citation/CS1/styles.css has no content.Teng SC, Wu KJ, Tseng SF, Wong CW, Kao L (Sep 2006). "Importin KPNA2, NBS1, DNA repair and tumorigenesis". Journal of Molecular Histology. 37 (5–7): 293–9. doi:10.1007/s10735-006-9032-y. PMID 16752129. S2CID 7281949.
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- Page Module:Citation/CS1/styles.css has no content.Küssel P, Frasch M (Aug 1995). "Yeast Srp1, a nuclear protein related to Drosophila and mouse pendulin, is required for normal migration, division, and integrity of nuclei during mitosis". Molecular & General Genetics. 248 (3): 351–63. doi:10.1007/BF02191602. PMID 7565597. S2CID 24877825.
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