Polyvinylpolypyrrolidone
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Template:Chembox IndexlistTemplate:Chembox CompToxTemplate:Chembox Datapage check| Names | |
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| IUPAC name
1-ethenylpyrrolidin-2-one
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| Other names
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| Identifiers | |
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| Abbreviations | PVPP |
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| A07BC03 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Template:Chembox Footer/trackingTemplate:Short description
Polyvinylpolypyrrolidone (polyvinyl polypyrrolidone, PVPP, crospovidone, crospolividone, or E1202) is a highly cross-linked modification of polyvinylpyrrolidone (PVP).
This cross-linked form of PVP is used as a disintegrant (see also excipients) in pharmaceutical tablets.[1]
PVPP is insoluble in water, though it still absorbs water and swells very rapidly generating a swelling force. This property makes it useful as a disintegrant in tablets.[citation needed]
PVPP can be used as a drug, taken as a tablet or suspension to absorb compounds (so-called endotoxins) that cause diarrhea. (Cf. bone char, charcoal.)[citation needed]
It is also used as a fining to extract impurities (via agglomeration followed by filtration). It is used in winemaking. Using the same principle it is used to remove polyphenols in beer production and thus clear beers with stable foam are produced.[2] One such commercial product is called Polyclar. PVPP forms bonds similar to peptidic bonds in protein (especially, like proline residues) and that is why it can precipitate tannins the same way as proteins do.[3]
PVPP is used as a stabiliser.[citation needed]
Safety
Autopsies have found that crospovidone/PVPP contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[4]
See also
References
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- ^ Page Module:Citation/CS1/styles.css has no content."Povidones, Copovidones, and Crospovidones for Pharmaceutical Products". BASF Pharma. Retrieved 2022-06-11.
- ^ Microsoft Word - G0294.doc[dead link]
- ^ Page Module:Citation/CS1/styles.css has no content."A Novel Stabilization of Beer with Polyclar Brewbrite. Mustafa Rehmanji, Chandra Gopal, and Andrew Mola, MBAA TQ vol. 39, no. 1, 2002, pp. 24–28" (PDF). Archived from the original (PDF) on 2015-09-06. Retrieved 2017-05-19.
- ^ Page Module:Citation/CS1/styles.css has no content.Ganesan, S; Felo, J; Saldana, M; Kalasinsky, V. F.; Lewin-Smith, M. R.; Tomashefski Jr, J. F. (2003). "Embolized crospovidone (polyN-vinyl-2-pyrrolidone) in the lungs of intravenous drug users". Modern Pathology. 16 (4): 286–92. doi:10.1097/01.MP.0000062653.65441.DA. PMID 12692192.
