TRAF interacting protein
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TRAF-interacting protein is a protein that in humans is encoded by the TRAIP gene.[2][3]
This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis.[3]
Interactions
TRAF interacting protein has been shown to interact with FLII,[4] TRAF1[2] and TRAF2.[2]
Role in mitotic DNA synthesis
Mitotic DNA synthesis (MiDAS) is thought to be a DNA repair mechanism to salvage DNA that has not finished replication during S phase, which may be due to DNA replication stress (RS).[5] Intrinsic sources of RS include transcription-replication conflicts and “difficult-to-replicate’’ regions.[5] Extrinsic RS includes exposure to genotoxic agents, depletion of dNTPs, and premature S phase activity which can occur in precancerous cells after oncogene activation.[5] Some MiDAS pathways require the TRAIP protein to disassemble the replication complex at the stalled replication fork in cases where RS causes the fork to stall during replication.[5]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Hoffmann S, Smedegaard S, Nakamura K, Mortuza GB, Räschle M, Ibañez de Opakua A, et al. (January 2016). "TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress". The Journal of Cell Biology. 212 (1): 63–75. doi:10.1083/jcb.201506071. PMC 4700480. PMID 26711499.
- ^ a b c Page Module:Citation/CS1/styles.css has no content.Lee SY, Lee SY, Choi Y (April 1997). "TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation". The Journal of Experimental Medicine. 185 (7): 1275–1285. doi:10.1084/jem.185.7.1275. PMC 2196258. PMID 9104814.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: TRAIP TRAF interacting protein".
- ^ Page Module:Citation/CS1/styles.css has no content.Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (August 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Research. 26 (15): 3460–3467. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
- ^ a b c d Page Module:Citation/CS1/styles.css has no content.Bhowmick R, Hickson ID, Liu Y (October 2023). "Completing genome replication outside of S phase". Molecular Cell. 83 (20): 3596–3607. doi:10.1016/j.molcel.2023.08.023. PMID 37716351.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Beckly JB, Hancock L, Geremia A, Cummings JR, Morris A, Cooney R, et al. (April 2008). "Two-stage candidate gene study of chromosome 3p demonstrates an association between nonsynonymous variants in the MST1R gene and Crohn's disease". Inflammatory Bowel Diseases. 14 (4): 500–507. doi:10.1002/ibd.20365. PMID 18200509. S2CID 37697301.
- Page Module:Citation/CS1/styles.css has no content.Regamey A, Hohl D, Liu JW, Roger T, Kogerman P, Toftgard R, et al. (December 2003). "The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor". The Journal of Experimental Medicine. 198 (12): 1959–1964. doi:10.1084/jem.20031187. PMC 2194148. PMID 14676304.
- Page Module:Citation/CS1/styles.css has no content.Wilson SA, Brown EC, Kingsman AJ, Kingsman SM (August 1998). "TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I". Nucleic Acids Research. 26 (15): 3460–3467. doi:10.1093/nar/26.15.3460. PMC 147727. PMID 9671805.
- Page Module:Citation/CS1/styles.css has no content.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Page Module:Citation/CS1/styles.css has no content.Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
External links
- TRAIP human gene location in the UCSC Genome Browser.
- TRAIP human gene details in the UCSC Genome Browser.
