Triethylenemelamine

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(Redirected from Tretamine)

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Triethylenemelamine
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Clinical data
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  • None
Identifiers
  • 2,4,6-Tris(aziridin-1-yl)-1,3,5-triazine
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Chemical and physical data
FormulaC9H12N6
Molar mass204.237 g·mol−1
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  • C1CN1c2nc(nc(n2)N3CC3)N4CC4
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Triethylenemelamine (abbreviated TEM, also called Tretamine) is a drug used in chemotherapy.[1]

It is a mutagenic chemical because it is an alkylating antineoplastic agent, a trifunctional alkylating agent that has three reactive groups that enable it to bind covalently to DNA at three distinct sites. As a result, TEM can cause chromatid aberrations in cell models.[2] It was one of the first compounds used for chemical mutagenesis in laboratory mice, with the impact on mutagenesis measured by the specific-locus test by Bruce Cattanach.[3]

See also

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Wong JR, Morton LM, Tucker MA, Abramson DH, Seddon JM, Sampson JN, Kleinerman RA (October 2014). "Risk of subsequent malignant neoplasms in long-term hereditary retinoblastoma survivors after chemotherapy and radiotherapy". Journal of Clinical Oncology. 32 (29): 3284–3290. doi:10.1200/JCO.2013.54.7844. PMC 4178525. PMID 25185089.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Luippold HE, Gooch PC, Brewen JG (February 1978). "The production of chromosome aberrations in various mammalian cells by triethylenemelamine". Genetics. 88 (2): 317–326. doi:10.1093/genetics/88.2.317. PMC 1213803. PMID 565312.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Cattanach, B. M. (1966). "Chemically induced mutations in mice". Mutation Research. 3 (4): 346–353. doi:10.1016/0027-5107(66)90041-8. PMID 5969214.

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