CDC27

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Template:Short description Template:Cs1 configLua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.[1][2]

Function

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis.[2]

Interactions

CDC27 has been shown to interact with:

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References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Tugendreich S, Boguski MS, Seldin MS, Hieter P (Nov 1993). "Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base". Proceedings of the National Academy of Sciences of the United States of America. 90 (21): 10031–5. Bibcode:1993PNAS...9010031T. doi:10.1073/pnas.90.21.10031. PMC 47707. PMID 8234252.
  2. ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CDC27 cell division cycle 27 homolog (S. cerevisiae)".
  3. ^ a b c d e f g h i j Page Module:Citation/CS1/styles.css has no content.Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/s0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
  4. ^ a b c d e f g Page Module:Citation/CS1/styles.css has no content.Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (Nov 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
  6. ^ Page Module:Citation/CS1/styles.css has no content.Koloteva-Levine N, Pinchasi D, Pereman I, Zur A, Brandeis M, Elroy-Stein O (May 2004). "The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation". Molecular and Cellular Biology. 24 (9): 3577–87. doi:10.1128/mcb.24.9.3577-3587.2004. PMC 387753. PMID 15082755.
  7. ^ a b c Page Module:Citation/CS1/styles.css has no content.Kallio M, Weinstein J, Daum JR, Burke DJ, Gorbsky GJ (Jun 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". The Journal of Cell Biology. 141 (6): 1393–406. doi:10.1083/jcb.141.6.1393. PMC 2132789. PMID 9628895.
  8. ^ Page Module:Citation/CS1/styles.css has no content.Ollendorff V, Donoghue DJ (Dec 1997). "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex". The Journal of Biological Chemistry. 272 (51): 32011–8. doi:10.1074/jbc.272.51.32011. PMID 9405394.
  9. ^ a b Page Module:Citation/CS1/styles.css has no content.Kramer ER, Gieffers C, Hölzl G, Hengstschläger M, Peters JM (Nov 1998). "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family". Current Biology. 8 (22): 1207–10. Bibcode:1998CBio....8.1207K. doi:10.1016/s0960-9822(07)00510-6. PMID 9811605. S2CID 17181162.
  10. ^ Page Module:Citation/CS1/styles.css has no content.D'Angiolella V, Mari C, Nocera D, Rametti L, Grieco D (Oct 2003). "The spindle checkpoint requires cyclin-dependent kinase activity". Genes & Development. 17 (20): 2520–5. doi:10.1101/gad.267603. PMC 218146. PMID 14561775.
  11. ^ Page Module:Citation/CS1/styles.css has no content.Kallio MJ, Beardmore VA, Weinstein J, Gorbsky GJ (Sep 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". The Journal of Cell Biology. 158 (5): 841–7. doi:10.1083/jcb.200201135. PMC 2173153. PMID 12196507.
  12. ^ a b Page Module:Citation/CS1/styles.css has no content.Wassmann K, Benezra R (Sep 1998). "Mad2 transiently associates with an APC/p55Cdc complex during mitosis". Proceedings of the National Academy of Sciences of the United States of America. 95 (19): 11193–8. Bibcode:1998PNAS...9511193W. doi:10.1073/pnas.95.19.11193. PMC 21618. PMID 9736712.
  13. ^ Page Module:Citation/CS1/styles.css has no content.Nilsson J, Yekezare M, Minshull J, Pines J (Dec 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nature Cell Biology. 10 (12): 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.
  14. ^ Page Module:Citation/CS1/styles.css has no content.Zhou Y, Ching YP, Ng RW, Jin DY (Sep 2003). "Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1". The Biochemical Journal. 374 (Pt 2): 349–58. doi:10.1042/BJ20030600. PMC 1223613. PMID 12797865.
  15. ^ Page Module:Citation/CS1/styles.css has no content.Shen M, Stukenberg PT, Kirschner MW, Lu KP (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes & Development. 12 (5): 706–20. doi:10.1101/gad.12.5.706. PMC 316589. PMID 9499405.
  16. ^ Page Module:Citation/CS1/styles.css has no content.Lu PJ, Zhou XZ, Shen M, Lu KP (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". Science. 283 (5406): 1325–8. Bibcode:1999Sci...283.1325L. doi:10.1126/science.283.5406.1325. PMID 10037602.

Further reading

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