MX1
From Wikipedia, the free encyclopedia
Template:Short description Template:Cs1 config Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value).
Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.[1][2]
In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Furthermore, the human orthologue MxA is a major host determinant for influenza viruses of animal origin.[3] The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases.[2]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Haller O, Staeheli P, Kochs G (Jul 2007). "Interferon-induced Mx proteins in antiviral host defense". Biochimie. 89 (6–7): 812–818. doi:10.1016/j.biochi.2007.04.015. PMID 17570575.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)".
- ^ Page Module:Citation/CS1/styles.css has no content.Ciminski K, Chase G, Beer M, Schwemmle M (Feb 2021). "Influenza A Viruses: Understanding Human Host Determinants". Trends in Molecular Medicine. 27 (2): 104–112. doi:10.1016/j.molmed.2020.09.014. PMID 33097424. S2CID 225058479.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Pavlovic J, Haller O, Staeheli P (Apr 1992). "Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle". Journal of Virology. 66 (4): 2564–2569. doi:10.1128/JVI.66.4.2564-2569.1992. PMC 289059. PMID 1548781.
- Page Module:Citation/CS1/styles.css has no content.Horisberger MA (Aug 1992). "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins". Journal of Virology. 66 (8): 4705–4709. doi:10.1128/JVI.66.8.4705-4709.1992. PMC 241296. PMID 1629950.
- Page Module:Citation/CS1/styles.css has no content.Petersen MB, Slaugenhaupt SA, Lewis JG, Warren AC, Chakravarti A, Antonarakis SE (Mar 1991). "A genetic linkage map of 27 markers on human chromosome 21". Genomics. 9 (3): 407–419. doi:10.1016/0888-7543(91)90406-5. PMID 1674496.
- Page Module:Citation/CS1/styles.css has no content.Horisberger MA, McMaster GK, Zeller H, Wathelet MG, Dellis J, Content J (Mar 1990). "Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter". Journal of Virology. 64 (3): 1171–1181. doi:10.1128/JVI.64.3.1171-1181.1990. PMC 249231. PMID 2154602.
- Page Module:Citation/CS1/styles.css has no content.Pavlovic J, Zürcher T, Haller O, Staeheli P (Jul 1990). "Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein". Journal of Virology. 64 (7): 3370–3375. doi:10.1128/JVI.64.7.3370-3375.1990. PMC 249583. PMID 2161946.
- Page Module:Citation/CS1/styles.css has no content.Aebi M, Fäh J, Hurt N, et al. (Nov 1989). "cDNA structures and regulation of two interferon-induced human Mx proteins". Molecular and Cellular Biology. 9 (11): 5062–5072. doi:10.1128/mcb.9.11.5062. PMC 363658. PMID 2481229.
- Page Module:Citation/CS1/styles.css has no content.Weitz G, Bekisz J, Zoon K, Arnheiter H (Dec 1989). "Purification and characterization of a human Mx protein". Journal of Interferon Research. 9 (6): 679–689. doi:10.1089/jir.1989.9.679. PMID 2607176.
- Page Module:Citation/CS1/styles.css has no content.Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Page Module:Citation/CS1/styles.css has no content.Melen K, Keskinen P, Ronni T, Sareneva T, Lounatmaa K, Julkunen I (Sep 1996). "Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope". Journal of Biological Chemistry. 271 (38): 23478–23486. doi:10.1074/jbc.271.38.23478. PMID 8798556.
- Page Module:Citation/CS1/styles.css has no content.Ponten A, Sick C, Weeber M, Haller O, Kochs G (Apr 1997). "Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity". Journal of Virology. 71 (4): 2591–2599. doi:10.1128/JVI.71.4.2591-2599.1997. PMC 191379. PMID 9060610.
- Page Module:Citation/CS1/styles.css has no content.Fernández M, Quiroga JA, Martín J, et al. (Apr 1997). "Impaired interferon induction of human MxA protein in chronic hepatitis B virus infection". Journal of Medical Virology. 51 (4): 332–337. doi:10.1002/(SICI)1096-9071(199704)51:4<332::AID-JMV12>3.0.CO;2-K. PMID 9093949. S2CID 12578068.
- Page Module:Citation/CS1/styles.css has no content.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Page Module:Citation/CS1/styles.css has no content.Li Y, Youssoufian H (Dec 1997). "MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups". The Journal of Clinical Investigation. 100 (11): 2873–2880. doi:10.1172/JCI119836. PMC 508494. PMID 9389754.
- Page Module:Citation/CS1/styles.css has no content.Kochs G, Trost M, Janzen C, Haller O (Jul 1998). "MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures". Methods. 15 (3). San Diego, Calif.: 255–263. doi:10.1006/meth.1998.0629. PMID 9735310.
- Page Module:Citation/CS1/styles.css has no content.Weber F, Haller O, Kochs G (Jan 2000). "MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes". Journal of Virology. 74 (1): 560–563. doi:10.1128/JVI.74.1.560-563.2000. PMC 111572. PMID 10590150.
- Page Module:Citation/CS1/styles.css has no content.Hijikata M, Ohta Y, Mishiro S (2000). "Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon". Intervirology. 43 (2): 124–127. doi:10.1159/000025035. PMID 10971132. S2CID 19445539.
- Page Module:Citation/CS1/styles.css has no content.Engelhardt OG, Ullrich E, Kochs G, Haller O (Dec 2001). "Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies". Experimental Cell Research. 271 (2): 286–295. doi:10.1006/excr.2001.5380. PMID 11716541.
- Page Module:Citation/CS1/styles.css has no content.Hijikata M, Mishiro S, Miyamoto C, Furuichi Y, Hashimoto M, Ohta Y (2002). "Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro". Intervirology. 44 (6): 379–382. doi:10.1159/000050075. PMID 11805446. S2CID 46752867.
- Page Module:Citation/CS1/styles.css has no content.Kochs G, Haener M, Aebi U, Haller O (Apr 2002). "Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomers". Journal of Biological Chemistry. 277 (16): 14172–14176. doi:10.1074/jbc.M200244200. PMID 11847228.
