SUB1
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Template:Cs1 config Template:Short description Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded by the SUB1 gene.[1][2][3] The human SUB1 gene[3] is named after an orthologous gene in yeast.[4]
SUB1 is induced by oxidative stress, and is involved in coordinating cellular responses to DNA strand breaks that arise after oxidative stress.Page Module:Citation/CS1/styles.css has no content.Yu L, Ma H, Ji X, Volkert MR (January 2016). "The Sub1 nuclear protein protects DNA from oxidative damage". Molecular and Cellular Biochemistry. 412 (1–2): 165–171. doi:10.1007/s11010-015-2621-x. PMC 5064834. PMID 26708217. Yeast SUB1 has structural and functional similarities to human alpha-synuclein, a protein that has an important role in Parkinson's disease.Page Module:Citation/CS1/styles.css has no content.Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, et al. (July 2019). "Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders". Scientific Reports. 9 (1): 10919. doi:10.1038/s41598-019-47227-z. PMC 6662836. PMID 31358782. Like SUB1, alpha-synuclein functions in regulating DNA repair including repair of DNA double-strand breaks.
Interactions
SUB1 has been shown to interact with CSTF2.[5]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Kretzschmar M, Kaiser K, Lottspeich F, Meisterernst M (August 1994). "A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators". Cell. 78 (3): 525–534. doi:10.1016/0092-8674(94)90429-4. PMID 8062392. S2CID 29077941.
- ^ Page Module:Citation/CS1/styles.css has no content.Ge H, Roeder RG (August 1994). "Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes". Cell. 78 (3): 513–523. doi:10.1016/0092-8674(94)90428-6. PMID 8062391. S2CID 1140379.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene SUB1: SUB1 homolog (S. cerevisiae)".
- ^ Page Module:Citation/CS1/styles.css has no content.Knaus R, Pollock R, Guarente L (April 1996). "Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4". The EMBO Journal. 15 (8): 1933–1940. doi:10.1002/j.1460-2075.1996.tb00544.x. PMC 450112. PMID 8617240.
- ^ Page Module:Citation/CS1/styles.css has no content.Calvo O, Manley JL (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Molecular Cell. 7 (5): 1013–1023. doi:10.1016/S1097-2765(01)00236-2. PMID 11389848.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Kaiser K, Stelzer G, Meisterernst M (July 1995). "The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation". The EMBO Journal. 14 (14): 3520–3527. doi:10.1002/j.1460-2075.1995.tb07358.x. PMC 394420. PMID 7628453.
- Page Module:Citation/CS1/styles.css has no content.Ge H, Zhao Y, Chait BT, Roeder RG (December 1994). "Phosphorylation negatively regulates the function of coactivator PC4". Proceedings of the National Academy of Sciences of the United States of America. 91 (26): 12691–12695. doi:10.1073/pnas.91.26.12691. PMC 45505. PMID 7809103.
- Page Module:Citation/CS1/styles.css has no content.Brandsen J, Werten S, van der Vliet PC, Meisterernst M, Kroon J, Gros P (November 1997). "C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site". Nature Structural Biology. 4 (11): 900–903. doi:10.1038/nsb1197-900. PMID 9360603. S2CID 30710386.
- Page Module:Citation/CS1/styles.css has no content.Malik S, Guermah M, Roeder RG (March 1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proceedings of the National Academy of Sciences of the United States of America. 95 (5): 2192–2197. Bibcode:1998PNAS...95.2192M. doi:10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861.
- Page Module:Citation/CS1/styles.css has no content.Luo Y, Ge H, Stevens S, Xiao H, Roeder RG (July 1998). "Coactivation by OCA-B: definition of critical regions and synergism with general cofactors". Molecular and Cellular Biology. 18 (7): 3803–3810. doi:10.1128/mcb.18.7.3803. PMC 108964. PMID 9632764.
- Page Module:Citation/CS1/styles.css has no content.Currie RA (July 1998). "Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development". The Journal of Biological Chemistry. 273 (29): 18220–18229. doi:10.1074/jbc.273.29.18220. PMID 9660784.
- Page Module:Citation/CS1/styles.css has no content.Wang Z, Roeder RG (April 1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III". Molecular Cell. 1 (5): 749–757. doi:10.1016/S1097-2765(00)80074-X. PMID 9660958.
- Page Module:Citation/CS1/styles.css has no content.Holloway AF, Occhiodoro F, Mittler G, Meisterernst M, Shannon MF (July 2000). "Functional interaction between the HIV transactivator Tat and the transcriptional coactivator PC4 in T cells". The Journal of Biological Chemistry. 275 (28): 21668–21677. doi:10.1074/jbc.M909058199. PMID 10887206.
- Page Module:Citation/CS1/styles.css has no content.Yuan CX, Gurley WB (July 2000). "Potential targets for HSF1 within the preinitiation complex". Cell Stress & Chaperones. 5 (3): 229–242. PMC 312889. PMID 11005381.
- Page Module:Citation/CS1/styles.css has no content.Kumar BR, Swaminathan V, Banerjee S, Kundu TK (May 2001). "p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation". The Journal of Biological Chemistry. 276 (20): 16804–16809. doi:10.1074/jbc.M100934200. PMID 11279157.
- Page Module:Citation/CS1/styles.css has no content.Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, et al. (January 2001). "p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues". Oncogene. 20 (4): 484–489. doi:10.1038/sj.onc.1204113. PMID 11313979. S2CID 39144360.
- Page Module:Citation/CS1/styles.css has no content.Calvo O, Manley JL (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Molecular Cell. 7 (5): 1013–1023. doi:10.1016/S1097-2765(01)00236-2. PMID 11389848.
- Page Module:Citation/CS1/styles.css has no content.Dubois T, Zemlickova E, Howell S, Aitken A (February 2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochemical and Biophysical Research Communications. 301 (2): 502–508. doi:10.1016/S0006-291X(02)03010-3. PMID 12565890.
- Page Module:Citation/CS1/styles.css has no content.Fukuda A, Tokonabe S, Hamada M, Matsumoto M, Tsukui T, Nogi Y, Hisatake K (April 2003). "Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH". The Journal of Biological Chemistry. 278 (17): 14827–14831. doi:10.1074/jbc.M213172200. PMID 12590132.
- Page Module:Citation/CS1/styles.css has no content.Swietlicki E, Iordanov H, Fritsch C, Yi L, Levin MS, Rubin DC (2003). "Growth factor regulation of PC4/TIS7, an immediate early gene expressed during gut adaptation after resection". Journal of Parenteral and Enteral Nutrition. 27 (2): 123–131. doi:10.1177/0148607103027002123. PMID 12665168.
- Page Module:Citation/CS1/styles.css has no content.Banerjee S, Kumar BR, Kundu TK (March 2004). "General transcriptional coactivator PC4 activates p53 function". Molecular and Cellular Biology. 24 (5): 2052–2062. doi:10.1128/MCB.24.5.2052-2062.2004. PMC 350566. PMID 14966284.
- Page Module:Citation/CS1/styles.css has no content.Caldwell RB, Braselmann H, Schoetz U, Heuer S, Scherthan H, Zitzelsberger H (July 2016). "Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cells". Scientific Reports. 6 28890. Bibcode:2016NatSR...628890C. doi:10.1038/srep28890. PMC 4931448. PMID 27374870.
External links
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