ADARB1
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Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.[1][2][3] The enzyme is a member of ADAR family.
Function
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rats found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an Alu cassette insert and a short or long C-terminal region.[3]
ADARB1 requires the small molecule inositol hexakisphosphate (IP6) for proper function.[4] ADARB1 is an A-to-I RNA-editing enzyme that mostly acts on protein-coding substrates.[5]
See also
- Adenosine deaminase (ADA), an enzyme acting on isolated adenosine
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Mittaz L, Scott HS, Rossier C, Seeburg PH, Higuchi M, Antonarakis SE (April 1997). "Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3". Genomics. 41 (2): 210–7. doi:10.1006/geno.1997.4655. PMID 9143496.
- ^ Page Module:Citation/CS1/styles.css has no content.Keegan LP, Leroy A, Sproul D, O'Connell MA (Feb 2004). "Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes". Genome Biology. 5 (2): 209. doi:10.1186/gb-2004-5-2-209. PMC 395743. PMID 14759252.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)".
- ^ Page Module:Citation/CS1/styles.css has no content.Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL (September 2005). "Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing". Science. 309 (5740): 1534–9. Bibcode:2005Sci...309.1534M. doi:10.1126/science.1113150. PMC 1850959. PMID 16141067.
- ^ Page Module:Citation/CS1/styles.css has no content.Licht K, Jantsch MF (April 2016). "Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications". The Journal of Cell Biology. 213 (1): 15–22. doi:10.1083/jcb.201511041. PMC 4828693. PMID 27044895.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Valenzuela A, Blanco J, Callebaut C, Jacotot E, Lluis C, Hovanessian AG, Franco R (1997). "HIV-1 Envelope gp120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26". Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology. Vol. 421. pp. 185–92. doi:10.1007/978-1-4757-9613-1_24. ISBN 978-1-4757-9615-5. PMID 9330696.
- Page Module:Citation/CS1/styles.css has no content.Melcher T, Maas S, Herb A, Sprengel R, Seeburg PH, Higuchi M (February 1996). "A mammalian RNA editing enzyme". Nature. 379 (6564): 460–4. Bibcode:1996Natur.379..460M. doi:10.1038/379460a0. PMID 8559253. S2CID 4326456.
- Page Module:Citation/CS1/styles.css has no content.O'Connell MA, Gerber A, Keller W (January 1997). "Purification of human double-stranded RNA-specific editase 1 (hRED1) involved in editing of brain glutamate receptor B pre-mRNA" (PDF). The Journal of Biological Chemistry. 272 (1): 473–8. doi:10.1074/jbc.272.1.473. PMID 8995285.
- Page Module:Citation/CS1/styles.css has no content.Valenzuela A, Blanco J, Callebaut C, Jacotot E, Lluis C, Hovanessian AG, Franco R (April 1997). "Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles". Journal of Immunology. 158 (8): 3721–9. doi:10.4049/jimmunol.158.8.3721. PMID 9103436.
- Page Module:Citation/CS1/styles.css has no content.Lai F, Chen CX, Carter KC, Nishikura K (May 1997). "Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases". Molecular and Cellular Biology. 17 (5): 2413–24. doi:10.1128/MCB.17.5.2413. PMC 232090. PMID 9111310.
- Page Module:Citation/CS1/styles.css has no content.Yang JH, Sklar P, Axel R, Maniatis T (April 1997). "Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing". Proceedings of the National Academy of Sciences of the United States of America. 94 (9): 4354–9. Bibcode:1997PNAS...94.4354Y. doi:10.1073/pnas.94.9.4354. PMC 20726. PMID 9113993.
- Page Module:Citation/CS1/styles.css has no content.Gerber A, O'Connell MA, Keller W (May 1997). "Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette". RNA. 3 (5): 453–63. PMC 1369496. PMID 9149227.
- Page Module:Citation/CS1/styles.css has no content.Villard L, Tassone F, Haymowicz M, Welborn R, Gardiner K (March 1997). "Map location, genomic organization and expression patterns of the human RED1 RNA editase". Somatic Cell and Molecular Genetics. 23 (2): 135–45. doi:10.1007/BF02679972. PMID 9330641. S2CID 45104326.
- Page Module:Citation/CS1/styles.css has no content.Blanco J, Valenzuela A, Herrera C, Lluís C, Hovanessian AG, Franco R (July 2000). "The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression". FEBS Letters. 477 (1–2): 123–8. Bibcode:2000FEBSL.477..123B. doi:10.1016/S0014-5793(00)01751-8. PMID 10899322. S2CID 22229481.
- Page Module:Citation/CS1/styles.css has no content.Herrera C, Morimoto C, Blanco J, Mallol J, Arenzana F, Lluis C, Franco R (June 2001). "Comodulation of CXCR4 and CD26 in human lymphocytes". The Journal of Biological Chemistry. 276 (22): 19532–9. doi:10.1074/jbc.M004586200. PMID 11278278.
- Page Module:Citation/CS1/styles.css has no content.Maas S, Patt S, Schrey M, Rich A (December 2001). "Underediting of glutamate receptor GluR-B mRNA in malignant gliomas". Proceedings of the National Academy of Sciences of the United States of America. 98 (25): 14687–92. Bibcode:2001PNAS...9814687M. doi:10.1073/pnas.251531398. PMC 64742. PMID 11717408.
- Page Module:Citation/CS1/styles.css has no content.Jayan GC, Casey JL (April 2002). "Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2". Journal of Virology. 76 (8): 3819–27. doi:10.1128/JVI.76.8.3819-3827.2002. PMC 136091. PMID 11907222.
- Page Module:Citation/CS1/styles.css has no content.Jaikaran DC, Collins CH, MacMillan AM (October 2002). "Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site" (PDF). The Journal of Biological Chemistry. 277 (40): 37624–9. doi:10.1074/jbc.M204126200. PMID 12163487.
- Page Module:Citation/CS1/styles.css has no content.Jayan GC, Casey JL (December 2002). "Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression". Journal of Virology. 76 (23): 12399–404. doi:10.1128/JVI.76.23.12399-12404.2002. PMC 136899. PMID 12414985.
- Page Module:Citation/CS1/styles.css has no content.Slavov D, Gardiner K (October 2002). "Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns". Gene. 299 (1–2): 83–94. doi:10.1016/S0378-1119(02)01016-8. PMID 12459255.
External links
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