ALX1
From Wikipedia, the free encyclopedia
Template:Short description An Error has occurred retrieving Wikidata item for infobox ALX homeobox protein 1 is a protein that in humans is encoded by the ALX1 gene.[1][2][3]
Function
The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly.[3]
In Burmese cats, especially the lineage known as Contemporary Burmese, a deletion of four aminoacids in ALX1 is common. When heterozygous, the mutation causes brachycephaly; when homozygous it causes a fatal head malformation known as Burmese head defect.[4]
In Darwin's finches, inhabiting the Galápagos islands, ALX1 has been linked to the diversity of beak shapes.[5]
Interactions
ALX1 has been shown to interact with IPO13.[6]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Gordon DF, Wagner J, Atkinson BL, Chiono M, Berry R, Sikela J, Gutierrez-Hartmann A (Jul 1996). "Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA". DNA and Cell Biology. 15 (7): 531–41. doi:10.1089/dna.1996.15.531. PMID 8756334.
- ^ Page Module:Citation/CS1/styles.css has no content.Régnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC (Oct 1995). "Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma". The Journal of Biological Chemistry. 270 (43): 25715–21. doi:10.1074/jbc.270.43.25715. PMID 7592751.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CART1 cartilage paired-class homeoprotein 1".
- ^ Page Module:Citation/CS1/styles.css has no content."Burmese - Burmese Head Defect". Universities Federation for Animal Welfare. Retrieved 7 June 2023.
- ^ Page Module:Citation/CS1/styles.css has no content.Lamichhaney S, Berglund J, Almén MS, Maqbool K, Grabherr M, Martinez-Barrio A, Promerová M, Rubin CJ, Wang Zamani N, Grant BR, Webster MT, Andersson L (11 February 2015). "Evolution of Darwin's finches and their beaks revealed by genome sequencing". Nature. 518 (7539): 371–5. Bibcode:2015Natur.518..371L. doi:10.1038/nature14181. PMID 25686609. S2CID 4462253.
- ^ Page Module:Citation/CS1/styles.css has no content.Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Zhao GQ, Zhou X, Eberspaecher H, Solursh M, de Crombrugghe B (Sep 1993). "Cartilage homeoprotein 1, a homeoprotein selectively expressed in chondrocytes". Proceedings of the National Academy of Sciences of the United States of America. 90 (18): 8633–7. Bibcode:1993PNAS...90.8633Z. doi:10.1073/pnas.90.18.8633. PMC 47412. PMID 7690966.
- Page Module:Citation/CS1/styles.css has no content.Zhao Q, Behringer RR, de Crombrugghe B (Jul 1996). "Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene". Nature Genetics. 13 (3): 275–83. doi:10.1038/ng0796-275. PMID 8673125. S2CID 12341689.
- Page Module:Citation/CS1/styles.css has no content.Cai RL (Sep 1998). "Human CART1, a paired-class homeodomain protein, activates transcription through palindromic binding sites". Biochemical and Biophysical Research Communications. 250 (2): 305–11. doi:10.1006/bbrc.1998.9257. PMID 9753625.
- Page Module:Citation/CS1/styles.css has no content.Qu S, Tucker SC, Zhao Q, deCrombrugghe B, Wisdom R (Jan 1999). "Physical and genetic interactions between Alx4 and Cart1". Development. 126 (2): 359–69. doi:10.1242/dev.126.2.359. PMID 9847249.
- Page Module:Citation/CS1/styles.css has no content.Iioka T, Furukawa K, Yamaguchi A, Shindo H, Yamashita S, Tsukazaki T (Aug 2003). "P300/CBP acts as a coactivator to cartilage homeoprotein-1 (Cart1), paired-like homeoprotein, through acetylation of the conserved lysine residue adjacent to the homeodomain". Journal of Bone and Mineral Research. 18 (8): 1419–29. doi:10.1359/jbmr.2003.18.8.1419. PMID 12929931. S2CID 8125330.
- Page Module:Citation/CS1/styles.css has no content.Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
