APIP

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Template:Short description Template:Cs1 config Lua error in Module:Infobox_gene at line 53: attempt to index field 'wikibase' (a nil value). APAF1-interacting protein is a protein that in humans is encoded by the APIP gene.[1][2][3] It is an enzyme with Methylthioribulose 1-phosphate dehydratase activity[4][5] which is involved in the methionine salvage pathway.

APIP deficiency is associated with cell death[6] and cancer.

Interactions

APIP has been shown to interact with APAF1.[2]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  2. ^ a b Page Module:Citation/CS1/styles.css has no content.Cho DH, Hong YM, Lee HJ, Woo HN, Pyo JO, Mak TW, Jung YK (Sep 2004). "Induced inhibition of ischemic/hypoxic injury by APIP, a novel Apaf-1-interacting protein". J Biol Chem. 279 (38): 39942–50. doi:10.1074/jbc.M405747200. PMID 15262985.
  3. ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: APIP APAF1 interacting protein".
  4. ^ Page Module:Citation/CS1/styles.css has no content.Mary C, Duek P, Salleron L, Tienz P, Bumann D, Bairoch A, Lane L (2012). Di Cunto F (ed.). "Functional Identification of APIP as Human mtnB, a Key Enzyme in the Methionine Salvage Pathway". PLOS ONE. 7 (12) e52877. Bibcode:2012PLoSO...752877M. doi:10.1371/journal.pone.0052877. PMC 3532061. PMID 23285211.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Kang W, Hong SH, Lee HM, Kim NY, Lim YC, Le Le TM, Lim B, Kim HC, Kim TY, Ashida H, Yokota A, Hah SS, Chun KH, Jung YK, Yang JK (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences. 111 (1): E54-61. Bibcode:2014PNAS..111E..54K. doi:10.1073/pnas.1308768111. PMC 3890807. PMID 24367089.
  6. ^ Page Module:Citation/CS1/styles.css has no content.Ko DC, Gamazon ER, Shukla KP, Pfuetzner RA, Whittington D, Holden TD, Brittnacher MJ, Fong C, Radey M, Ogohara C, Stark AL, Akey JM, Dolan ME, Wurfel MM, Miller SI (2012). "Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death". Proceedings of the National Academy of Sciences. 109 (35): E2343–E2352. doi:10.1073/pnas.1206701109. PMC 3435171. PMID 22837397.

Further reading

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