ATF7IP

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Template:Short description An Error has occurred retrieving Wikidata item for infobox Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.[1][2][3]

Interactions

ATF7IP has been shown to interact with MBD1.[4] In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark.[5][6]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
  2. ^ Page Module:Citation/CS1/styles.css has no content.De Graeve F, Bahr A, Chatton B, Kedinger C (Jun 2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene. 19 (14): 1807–19. doi:10.1038/sj.onc.1203492. PMID 10777215. S2CID 22900736.
  3. ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: ATF7IP activating transcription factor 7 interacting protein".
  4. ^ Page Module:Citation/CS1/styles.css has no content.Fujita, Naoyuki; Watanabe Sugiko; Ichimura Takaya; Ohkuma Yoshiaki; Chiba Tsutomu; Saya Hideyuki; Nakao Mitsuyoshi (Apr 2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. 23 (8). United States: 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. ISSN 0270-7306. PMC 152570. PMID 12665582.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Sin, Jun Hyung; Zuckerman, Cassandra; Cortez, Jessica T.; Eckalbar, Walter L.; Erle, David J.; Anderson, Mark S.; Waterfield, Michael R. (2019-09-02). "The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses". The Journal of Experimental Medicine. 216 (9): 2024–2037. doi:10.1084/jem.20182316. ISSN 1540-9538. PMC 6719416. PMID 31217192.
  6. ^ Page Module:Citation/CS1/styles.css has no content.Zhao, Zhipeng; Feng, Lu; Peng, Xuerun; Ma, Tingnan; Tong, Rongsheng; Zhong, Lei (2022). "Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response". Frontiers in Pharmacology. 13 1073713. doi:10.3389/fphar.2022.1073713. ISSN 1663-9812. PMC 9793902. PMID 36582533.

Further reading

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  • Template:UCSC gene info
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)


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