Afloqualone

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Afloqualone
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Clinical data
AHFS/Drugs.comInternational Drug Names
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  • none
Legal status
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Identifiers
  • 6-Amino-2-(fluoromethyl)-3-(2-methylphenyl)quinazolin-4-one
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Chemical and physical data
FormulaC16H14FN3O
Molar mass283.306 g·mol−1
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Afloqualone (Arofuto) is a quinazolinone family GABAergic drug and is an analogue of methaqualone developed in the 1970s by a team at Tanabe Seiyaku.[1] It has sedative and muscle-relaxant effects resulting from its agonist activity at the β subtype of the GABAa receptor[2] and has had some clinical use, although it causes photosensitization as a side-effect that can cause skin problems such as dermatitis.[3]

See also

References

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  1. ^ Page Template:Citation/styles.css has no content.US 3966731, Inoue I, Oine T, Yamada Y, Tani J, Ishida R, Ochiai T, "2-Fluoromethyl-3-o-tolyl-6-amino-4(3H)-quinazolinone", issued Script error: No such module "auto date formatter"., assigned to Tanabe Seiyaku Co Ltd 
  2. ^ Page Module:Citation/CS1/styles.css has no content.Ochiai T, Ishida R (June 1982). "Pharmacological studies on 6-amino-2-fluoromethyl-3-(O-tolyl)-4(3H)-quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity". Japanese Journal of Pharmacology. 32 (3): 427–38. doi:10.1254/jjp.32.427. PMID 7109348.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Ishikawa T, Kamide R, Niimura M (June 1994). "Photoleukomelanodermatitis (Kobori) induced by afloqualone". The Journal of Dermatology. 21 (6): 430–3. doi:10.1111/j.1346-8138.1994.tb01768.x. PMID 8064007. S2CID 7486566.

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