Alifedrine

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Alifedrine
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Clinical data
Other namesD-13625
Routes of
administration		Oral, intravenous[1][2]
Drug classβ-Adrenergic receptor partial agonist; Sympathomimetic
Identifiers
  • 1-cyclohexyl-3-[[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]amino]propan-1-one
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Chemical and physical data
FormulaC18H27NO2
Molar mass289.419 g·mol−1
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  • C[C@@H]([C@@H](C1=CC=CC=C1)O)NCCC(=O)C2CCCCC2
  • InChI=1S/C18H27NO2/c1-14(18(21)16-10-6-3-7-11-16)19-13-12-17(20)15-8-4-2-5-9-15/h3,6-7,10-11,14-15,18-19,21H,2,4-5,8-9,12-13H2,1H3/t14-,18-/m0/s1
  • Key:UEELVIXXTBPOCF-KSSFIOAISA-N
Data page
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Alifedrine (INNTooltip International Nonproprietary Name; developmental code name D-13625) is a drug described as a sympathomimetic and cardiotonic or positive inotropic agent which was never marketed.[3][4][5][6] It is a β-adrenergic receptor partial agonist and was studied in the treatment of heart failure.[4][1][2][7] The drug is taken by mouth or intravenously.[1][2] It is a β-hydroxylated substituted amphetamine derivative.[8]

See also

References

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  1. ^ a b c Page Module:Citation/CS1/styles.css has no content.Wan SK, Hoff W, Evans TR (1988). "Haemodynamic effects of intravenous and oral alifedrine in patients with cardiac failure". Current Medical Research and Opinion. 11 (4): 242–253. doi:10.1185/03007998809114243. PMID 3215041.
  2. ^ a b c Page Module:Citation/CS1/styles.css has no content.Anand IS, Hughes LO, Whittington JR, Raftery EB (1989). "Acute haemodynamic effects of different doses of alifedrine in congestive heart failure". European Journal of Clinical Pharmacology. 36 (4): 335–341. doi:10.1007/BF00558291. PMID 2737225.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 1-PA373. ISBN 978-1-4757-2085-3. Retrieved 29 August 2024.
  4. ^ a b Page Module:Citation/CS1/styles.css has no content.Morton IK, Hall JM (1999). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. p. 10. ISBN 978-0-7514-0499-9. Retrieved 29 August 2024.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Pharmaceutical Manufacturing Encyclopedia. Volumes 1-4. Elsevier Science. 2013. p. 155. ISBN 978-0-8155-1856-3. Retrieved 2024-08-29.
  6. ^ Page Module:Citation/CS1/styles.css has no content.Wainwright CL, Parratt JR (March 1988). "Alifedrine, a positive inotropic agent that moderately reduces the severity of ischaemia and reperfusion-induced ventricular arrhythmias". European Journal of Pharmacology. 147 (3): 373–380. doi:10.1016/0014-2999(88)90171-9. PMID 3378563.
  7. ^ Page Module:Citation/CS1/styles.css has no content.Metzenauer P, Dedecke R, Göbel H, Martorana PA, Stroman F, Szelenyi I (July 1989). "Effects of the novel beta-adrenergic partial agonist alifedrine on cardiac performance in dogs with acute ischemic left ventricular failure". Journal of Cardiovascular Pharmacology. 14 (1): 103–108. doi:10.1097/00005344-198907000-00018. PMID 2475700. S2CID 72099344.
  8. ^ Page Module:Citation/CS1/styles.css has no content."Alifedrine". PubChem. U.S. National Library of Medicine. Retrieved 29 August 2024.

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