Alnespirone

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Alnespirone
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Clinical data
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  • none
Identifiers
  • (+)-4-dihydro-2H-chromen-3-yl]-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione
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Chemical and physical data
FormulaC26H38N2O4
Molar mass442.600 g·mol−1
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  • Cl.O=C1N(C(=O)CC2(C1)CCCC2)CCCCN([C@H]3Cc4c(OC)cccc4OC3)CCC
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Alnespirone (S-20,499) is a selective 5-HT1A receptor full agonist of the azapirone chemical class.[1][2][3] It produces antidepressant, anxiolytic, and antiaggressive effects.[1][4]

See also

References

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  1. ^ a b Page Module:Citation/CS1/styles.css has no content.Griebel G, Misslin R, Pawlowski M, Guardiola Lemaître B, Guillaumet G, Bizot-Espiard J (1992). "Anxiolytic-like effects of a selective 5-HT1A agonist, S20244, and its enantiomers in mice". NeuroReport. 3 (1): 84–86. doi:10.1097/00001756-199201000-00022. PMID 1351756.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Simon P, Guardiola B, Bizot-Espiard J, Schiavi P, Costentin J (1992). "5-HT1A receptor agonists prevent in rats the yawning and penile erections induced by direct dopamine agonists". Psychopharmacology. 108 (1–2): 47–50. doi:10.1007/BF02245284. PMID 1357709. S2CID 22385029.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Astier B, Lambás Señas L, Soulière F, Schmitt P, Urbain N, Rentero N, Bert L, Denoroy L, Renaud B, Lesourd M, Muñoz C, Chouvet G (2003). "In vivo comparison of two 5-HT1A receptors agonists alnespirone (S-20499) and buspirone on locus coeruleus neuronal activity". Eur J Pharmacol. 459 (1): 17–26. doi:10.1016/S0014-2999(02)02814-5. PMID 12505530.
  4. ^ Page Module:Citation/CS1/styles.css has no content.de Boer SF, Koolhaas JM (December 2005). "5-HT1A and 5-HT1B receptor agonists and aggression: a pharmacological challenge of the serotonin deficiency hypothesis". Eur J Pharmacol. 526 (1–3): 125–139. doi:10.1016/j.ejphar.2005.09.065. PMID 16310183.

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