Antazoline

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Antazoline
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Clinical data
Trade namesVasocon-a
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		Topical (nasal, eye drops)
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Legal status
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Identifiers
  • N-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline
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Chemical and physical data
FormulaC17H19N3
Molar mass265.360 g·mol−1
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  • N\1=C(\NCC/1)CN(c2ccccc2)Cc3ccccc3
  • InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19)
  • Key:REYFJDPCWQRWAA-UHFFFAOYSA-N
Data page
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Antazoline is a 1st generation antihistamine with anticholinergic properties used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis.[2] To treat allergic conjunctivitis, antazoline can be combined in a solution with tetryzoline.[3] The drug is a Histamine H1 receptor antagonist:[4] selectively binding to but not activating the receptor, thereby blocking the actions of endogenous histamine and subsequently leading to the temporary relief of the negative symptoms brought on by histamine.

Research

A 2015 study on people aged 65 years of age or older linked the development of Alzheimer's disease and other forms of dementia to the "higher cumulative" use of first-generation antihistamines, due to their anticholinergic properties.[5]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content."Therapeutic Goods (Poisons Standard— June 2025) Instrument 2025" (pdf). Therapeutic Goods Administration (TGA). May 2025. Retrieved 31 August 2025.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Abelson MB, Allansmith MR, Friedlaender MH (August 1980). "Effects of topically applied occular decongestant and antihistamine". American Journal of Ophthalmology. 90 (2): 254–257. doi:10.1016/s0002-9394(14)74864-0. PMID 7425039.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Castillo M, Scott NW, Mustafa MZ, Mustafa MS, Azuara-Blanco A (June 2015). "Topical antihistamines and mast cell stabilisers for treating seasonal and perennial allergic conjunctivitis". The Cochrane Database of Systematic Reviews. 2015 (6) CD009566. doi:10.1002/14651858.CD009566.pub2. hdl:2164/6048. PMC 10616535. PMID 26028608.
  4. ^ Page Module:Citation/CS1/styles.css has no content.Noguchi S, Inukai T, Kuno T, Tanaka C (June 1992). "The suppression of olfactory bulbectomy-induced muricide by antidepressants and antihistamines via histamine H1 receptor blocking". Physiology & Behavior. 51 (6): 1123–1127. doi:10.1016/0031-9384(92)90297-f. PMID 1353628. S2CID 29562845.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Gray SL, Anderson ML, Dublin S, Hanlon JT, Hubbard R, Walker R, et al. (March 2015). "Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study". JAMA Internal Medicine. 175 (3): 401–407. doi:10.1001/jamainternmed.2014.7663. PMC 4358759. PMID 25621434.

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