CACNA1G
Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Calcium channel, voltage-dependent, T type, alpha 1G subunit, also known as CACNA1G or Cav3.1 is a protein which in humans is encoded by the CACNA1G gene.[1][2][3] It is one of the primary targets in the pharmacology of absence seizure.
Function
Cav3.1 is a type of low-voltage-activated calcium channel, also known as "T-type" for its transient on and off.[1] It is expressed in thalamocortical relay nucleus, and is responsible for the slow-wave sleep and absence seizure.[4] During a slow-wave sleep, Cav3.1 is put into burst mode, and a self-sustaining synchronous cycle between cortex and thalamus is formed, sensory inputs are isolated from cortex; while awake the thalamus should instead relay sensory inputs from outside the central nervous system. The mechanism of absence seizure has a lot in common with slow-wave sleep. Therefore, a blocker that inhibits the burst mode activation of Cav3.1 is effective in treating absence seizures. Common drugs including ethosuximide, as well as trimethadione.[4]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective Wikipedia articles. [§ 1]
- ^ The interactive pathway map can be edited at WikiPathways: Page Module:Citation/CS1/styles.css has no content."NicotineActivityonChromaffinCells_WP1603".
See also
References
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- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit".
- ^ Page Module:Citation/CS1/styles.css has no content.Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, et al. (February 1998). "Molecular characterization of a neuronal low-voltage-activated T-type calcium channel". Nature. 391 (6670): 896–900. Bibcode:1998Natur.391..896P. doi:10.1038/36110. PMID 9495342. S2CID 4373283.
- ^ Page Module:Citation/CS1/styles.css has no content.Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacological Reviews. 57 (4): 411–425. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Kopecky BJ, Liang R, Bao J (2014). "T-type Calcium Channel Blockers as Neuroprotective Agents". Pflügers Archiv: European Journal of Physiology. 466 (4): 757–765. doi:10.1007/s00424-014-1454-x. ISSN 0031-6768. PMC 4005039. PMID 24563219.
External links
- CACNA1G+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Template:UCSC gene info
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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