CCRL2
Template:Short description An Error has occurred retrieving Wikidata item for infobox C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.[1][2] Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.[3]
Function
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.[2]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Fan P, Kyaw H, Su K, Zeng Z, Augustus M, Carter KC, Li Y (Mar 1998). "Cloning and characterization of a novel human chemokine receptor". Biochem Biophys Res Commun. 243 (1): 264–8. doi:10.1006/bbrc.1997.7981. PMID 9473515.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2".
- ^ Page Module:Citation/CS1/styles.css has no content.Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC (September 2008). "Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis". J. Exp. Med. 205 (10): 2207–20. doi:10.1084/jem.20080300. PMC 2556791. PMID 18794339.
External links
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Daugherty BL, Springer MS (1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21". Genomics. 41 (2): 294–5. doi:10.1006/geno.1997.4626. PMID 9143512.
- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Galligan CL, Matsuyama W, Matsukawa A, et al. (2004). "Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis". Arthritis Rheum. 50 (6): 1806–14. doi:10.1002/art.20275. PMID 15188357.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Page Module:Citation/CS1/styles.css has no content.Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. Bibcode:2006Natur.440.1194M. doi:10.1038/nature04728. PMID 16641997.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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