CD37

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Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[1][2]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic transmembrane domains. Tetraspanins mediate signal transduction events that play a role in the regulation of immune responses, cell development, activation, growth and motility.[3][4][5][6] CD37 expression is restricted to cells of the immune system, with highest abundance on mature B cells, and lower expression is found on T cells and myeloid cells. CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternate splicing results in multiple transcript variants encoding different isoforms.[2] CD37 controls both humoral[7][8] and cellular immune responses.[9][10][11] CD37-deficiency in mice leads to spontaneous development on B cell lymphoma,[12] and patients with CD37-negative lymphomas have a worse clinical outcome.[13]

See also

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Virtaneva KI, Angelisová P, Baumruker T, Horejsí V, Nevanlinna H, Schröder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics. 37 (6): 461–5. doi:10.1007/BF00222471. hdl:10138/157839. PMID 8436422. S2CID 8899453.
  2. ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CD37 CD37 molecule".
  3. ^ Page Module:Citation/CS1/styles.css has no content.Levy S, Shoham T (February 2005). "The tetraspanin web modulates immune-signalling complexes". Nature Reviews. Immunology. 5 (2): 136–48. doi:10.1038/nri1548. PMID 15688041. S2CID 1756810.
  4. ^ Page Module:Citation/CS1/styles.css has no content.Charrin S, le Naour F, Silvie O, Milhiet PE, Boucheix C, Rubinstein E (May 2009). "Lateral organization of membrane proteins: tetraspanins spin their web". The Biochemical Journal. 420 (2): 133–54. doi:10.1042/BJ20082422. PMID 19426143.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Hemler ME (October 2005). "Tetraspanin functions and associated microdomains". Nature Reviews Molecular Cell Biology. 6 (10): 801–11. doi:10.1038/nrm1736. PMID 16314869. S2CID 5906694.
  6. ^ Page Module:Citation/CS1/styles.css has no content.van Deventer SJ, Dunlock VE, van Spriel AB (2017-06-15). "Molecular interactions shaping the tetraspanin web". Biochemical Society Transactions. 45 (3): 741–750. doi:10.1042/BST20160284. PMID 28620035.
  7. ^ Page Module:Citation/CS1/styles.css has no content.van Spriel AB, Sofi M, Gartlan KH, van der Schaaf A, Verschueren I, Torensma R, et al. (March 2009). "The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity". PLOS Pathogens. 5 (3) e1000338. doi:10.1371/journal.ppat.1000338. PMC 2650281. PMID 19282981.
  8. ^ Page Module:Citation/CS1/styles.css has no content.van Spriel AB, de Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, et al. (November 2012). "The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival". Science Signaling. 5 (250): ra82. doi:10.1126/scisignal.2003113. PMID 23150881. S2CID 21237789.
  9. ^ Page Module:Citation/CS1/styles.css has no content.Knobeloch KP, Wright MD, Ochsenbein AF, Liesenfeld O, Löhler J, Zinkernagel RM, et al. (August 2000). "Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions". Molecular and Cellular Biology. 20 (15): 5363–9. doi:10.1128/MCB.20.15.5363-5369.2000. PMC 85988. PMID 10891477.
  10. ^ Page Module:Citation/CS1/styles.css has no content.van Spriel AB, Puls KL, Sofi M, Pouniotis D, Hochrein H, Orinska Z, et al. (March 2004). "A regulatory role for CD37 in T cell proliferation". Journal of Immunology. 172 (5): 2953–61. doi:10.4049/jimmunol.172.5.2953. PMID 14978098. S2CID 5620186.
  11. ^ Page Module:Citation/CS1/styles.css has no content.Sheng KC, van Spriel AB, Gartlan KH, Sofi M, Apostolopoulos V, Ashman L, et al. (January 2009). "Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC". European Journal of Immunology. 39 (1): 50–5. doi:10.1002/eji.200838798. PMID 19089816. S2CID 46297687.
  12. ^ Page Module:Citation/CS1/styles.css has no content.de Winde CM, Veenbergen S, Young KH, Xu-Monette ZY, Wang XX, Xia Y, et al. (February 2016). "Tetraspanin CD37 protects against the development of B cell lymphoma". The Journal of Clinical Investigation. 126 (2): 653–66. doi:10.1172/JCI81041. PMC 4731177. PMID 26784544.
  13. ^ Page Module:Citation/CS1/styles.css has no content.Xu-Monette ZY, Li L, Byrd JC, Jabbar KJ, Manyam GC, Maria de Winde C, et al. (December 2016). "Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma". Blood. 128 (26): 3083–3100. doi:10.1182/blood-2016-05-715094. PMC 5201094. PMID 27760757.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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