CDC34
From Wikipedia, the free encyclopedia
Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1.[1][2][3] This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.[4]
CDC34 was originally discovered by work in baker's yeast as a gene that is essential for the cell cycle.[5] Cdc34 in yeast targets numerous substrates - notably the cyclin-dependent kinase inhibitor Sic1[6] - for ubiquitin-mediated protein degradation.[7] CDC34 is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[3]
Interactions
CDC34 has been shown to interact with CSNK2B,[8] BTRC[9][10] and CDK9.[11]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Plon SE, Leppig KA, Do HN, Groudine M (November 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proceedings of the National Academy of Sciences of the United States of America. 90 (22): 10484–8. Bibcode:1993PNAS...9010484P. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.
- ^ Page Module:Citation/CS1/styles.css has no content.Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, et al. (October 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proceedings of the National Academy of Sciences of the United States of America. 102 (42): 15053–8. Bibcode:2005PNAS..10215053G. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".
- ^ Page Module:Citation/CS1/styles.css has no content.Goebl MG, Yochem J, Jentsch S, McGrath JP, Varshavsky A, Byers B (September 1988). "The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme". Science. 241 (4871): 1331–5. Bibcode:1988Sci...241.1331G. doi:10.1126/science.2842867. PMID 2842867.
- ^ Page Module:Citation/CS1/styles.css has no content.Dutcher SK, Hartwell LH (February 1982). "The role of S. cerevisiae cell division cycle genes in nuclear fusion". Genetics. 100 (2): 175–84. doi:10.1093/genetics/100.2.175. PMC 1201806. PMID 7049831.
- ^ Page Module:Citation/CS1/styles.css has no content.King RW, Deshaies RJ, Peters JM, Kirschner MW (December 1996). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. Bibcode:1996Sci...274.1652K. doi:10.1126/science.274.5293.1652. PMID 8939846. S2CID 25369228.
- ^ Page Module:Citation/CS1/styles.css has no content.Williams KM, Qie S, Atkison JH, Salazar-Arango S, Alan Diehl J, Olsen SK (July 2019). "Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34". Nature Communications. 10 (1) 3296. Bibcode:2019NatCo..10.3296W. doi:10.1038/s41467-019-11061-8. PMC 6656757. PMID 31341161.
- ^ Page Module:Citation/CS1/styles.css has no content.Block K, Boyer TG, Yew PR (November 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". The Journal of Biological Chemistry. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.
- ^ Page Module:Citation/CS1/styles.css has no content.Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.
- ^ Page Module:Citation/CS1/styles.css has no content.Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
- ^ Page Module:Citation/CS1/styles.css has no content.Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, et al. (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular and Cellular Biology. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.
External links
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.King RW, Deshaies RJ, Peters JM, Kirschner MW (December 1996). "How proteolysis drives the cell cycle". Science. 274 (5293): 1652–9. Bibcode:1996Sci...274.1652K. doi:10.1126/science.274.5293.1652. PMID 8939846. S2CID 25369228.
- Page Module:Citation/CS1/styles.css has no content.Pagano M (November 1997). "Cell cycle regulation by the ubiquitin pathway". FASEB Journal. 11 (13): 1067–75. doi:10.1096/fasebj.11.13.9367342. PMID 9367342. S2CID 6368478.
- Page Module:Citation/CS1/styles.css has no content.Lisztwan J, Marti A, Sutterlüty H, Gstaiger M, Wirbelauer C, Krek W (January 1998). "Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway". The EMBO Journal. 17 (2): 368–83. doi:10.1093/emboj/17.2.368. PMC 1170388. PMID 9430629.
- Page Module:Citation/CS1/styles.css has no content.Song A, Wang Q, Goebl MG, Harrington MA (September 1998). "Phosphorylation of nuclear MyoD is required for its rapid degradation". Molecular and Cellular Biology. 18 (9): 4994–9. doi:10.1128/mcb.18.9.4994. PMC 109084. PMID 9710583.
- Page Module:Citation/CS1/styles.css has no content.Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, et al. (May 1999). "Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha". The Journal of Biological Chemistry. 274 (21): 14823–30. doi:10.1074/jbc.274.21.14823. PMID 10329681.
- Page Module:Citation/CS1/styles.css has no content.Pati D, Meistrich ML, Plon SE (July 1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis". Molecular and Cellular Biology. 19 (7): 5001–13. doi:10.1128/mcb.19.7.5001. PMC 84326. PMID 10373550.
- Page Module:Citation/CS1/styles.css has no content.Seol JH, Feldman RM, Zachariae W, Shevchenko A, Correll CC, Lyapina S, et al. (June 1999). "Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34". Genes & Development. 13 (12): 1614–26. doi:10.1101/gad.13.12.1614. PMC 316801. PMID 10385629.
- Page Module:Citation/CS1/styles.css has no content.Read MA, Brownell JE, Gladysheva TB, Hottelet M, Parent LA, Coggins MB, et al. (April 2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha". Molecular and Cellular Biology. 20 (7): 2326–33. doi:10.1128/MCB.20.7.2326-2333.2000. PMC 85397. PMID 10713156.
- Page Module:Citation/CS1/styles.css has no content.Reymond F, Wirbelauer C, Krek W (May 2000). "Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase". Journal of Cell Science. 113 ( Pt 10) (10): 1687–94. doi:10.1242/jcs.113.10.1687. PMID 10769200.
- Page Module:Citation/CS1/styles.css has no content.Charrasse S, Carena I, Brondani V, Klempnauer KH, Ferrari S (June 2000). "Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway". Oncogene. 19 (26): 2986–95. doi:10.1038/sj.onc.1203618. PMID 10871850.
- Page Module:Citation/CS1/styles.css has no content.Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, et al. (July 2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4". Oncogene. 19 (31): 3529–36. doi:10.1038/sj.onc.1203647. PMID 10918611.
- Page Module:Citation/CS1/styles.css has no content.Duan W, Sun B, Li TW, Tan BJ, Lee MK, Teo TS (October 2000). "Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo". Gene. 256 (1–2): 113–21. doi:10.1016/S0378-1119(00)00365-6. PMID 11054541.
- Page Module:Citation/CS1/styles.css has no content.Block K, Boyer TG, Yew PR (November 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". The Journal of Biological Chemistry. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.
- Page Module:Citation/CS1/styles.css has no content.Wu K, Chen A, Tan P, Pan ZQ (January 2002). "The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34". The Journal of Biological Chemistry. 277 (1): 516–27. doi:10.1074/jbc.M108008200. PMID 11675391.
- Page Module:Citation/CS1/styles.css has no content.Kiernan RE, Emiliani S, Nakayama K, Castro A, Labbé JC, Lorca T, et al. (December 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Molecular and Cellular Biology. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMC 99964. PMID 11689688.
- Page Module:Citation/CS1/styles.css has no content.Semplici F, Meggio F, Pinna LA, Oliviero S (June 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.
Lua error in package.lua at line 80: module 'Module:Navbox/configuration' not found. Lua error in package.lua at line 80: module 'Module:Navbox/configuration' not found.
