CDY1
Template:Short description An Error has occurred retrieving Wikidata item for infobox Testis-specific chromodomain protein Y 1 is a protein that in humans is encoded by the CDY1 gene.[1][2]
This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined.[2] The gene is thought to be related to high-altitude adaptation in humans.[3]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Lahn BT, Page DC (October 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–680. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CDY1 chromodomain protein, Y-linked, 1".
- ^ Page Module:Citation/CS1/styles.css has no content.Zhang YB, Li X, Zhang F, Wang DM, Yu J (2012). "A preliminary study of copy number variation in Tibetans". PLOS ONE. 7 (7) e41768. Bibcode:2012PLoSO...741768Z. doi:10.1371/journal.pone.0041768. PMC 3402393. PMID 22844521.
External links
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Jones DO, Cowell IG, Singh PB (February 2000). "Mammalian chromodomain proteins: their role in genome organisation and expression". BioEssays. 22 (2): 124–137. CiteSeerX 10.1.1.575.6410. doi:10.1002/(SICI)1521-1878(200002)22:2<124::AID-BIES4>3.0.CO;2-E. PMID 10655032.
- Page Module:Citation/CS1/styles.css has no content.Yen PH (November 1998). "A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males". Genomics. 54 (1): 5–12. doi:10.1006/geno.1998.5526. PMID 9806824.
- Page Module:Citation/CS1/styles.css has no content.Lahn BT, Page DC (April 1999). "Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome". Nature Genetics. 21 (4): 429–433. doi:10.1038/7771. PMID 10192397. S2CID 8345990.
- Page Module:Citation/CS1/styles.css has no content.Saut N, Terriou P, Navarro A, Lévy N, Mitchell MJ (September 2000). "The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility". Molecular Human Reproduction. 6 (9): 789–793. doi:10.1093/molehr/6.9.789. PMID 10956550.
- Page Module:Citation/CS1/styles.css has no content.Kleiman SE, Lagziel A, Yogev L, Botchan A, Paz G, Yavetz H (January 2001). "Expression of CDY1 may identify complete spermatogenesis". Fertility and Sterility. 75 (1): 166–173. doi:10.1016/S0015-0282(00)01639-3. PMID 11163833.
- Page Module:Citation/CS1/styles.css has no content.Ferlin A, Moro E, Rossi A, Foresta C (February 2001). "CDY1 analysis in infertile patients with DAZ deletions". Journal of Endocrinological Investigation. 24 (2): RC4–RC6. doi:10.1007/bf03343814. PMID 11263480. S2CID 22500357.
- Page Module:Citation/CS1/styles.css has no content.Lahn BT, Tang ZL, Zhou J, Barndt RJ, Parvinen M, Allis CD, Page DC (June 2002). "Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis". Proceedings of the National Academy of Sciences of the United States of America. 99 (13): 8707–8712. Bibcode:2002PNAS...99.8707L. doi:10.1073/pnas.082248899. PMC 124363. PMID 12072557.
- Page Module:Citation/CS1/styles.css has no content.Kostova E, Röttger S, Schempp W, Gromoll J (August 2002). "Identification and characterization of the cynomolgus monkey chromodomain gene cynCDY, an orthologue of the human CDY gene family". Molecular Human Reproduction. 8 (8): 702–709. doi:10.1093/molehr/8.8.702. PMID 12149400.
- Page Module:Citation/CS1/styles.css has no content.Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, et al. (June 2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–837. Bibcode:2003Natur.423..825S. doi:10.1038/nature01722. PMID 12815422.
- Page Module:Citation/CS1/styles.css has no content.Dorus S, Gilbert SL, Forster ML, Barndt RJ, Lahn BT (July 2003). "The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence". Human Molecular Genetics. 12 (14): 1643–1650. doi:10.1093/hmg/ddg185. PMID 12837688.
- Page Module:Citation/CS1/styles.css has no content.Kleiman SE, Yogev L, Hauser R, Botchan A, Bar-Shira Maymon B, Schreiber L, et al. (November 2003). "Members of the CDY family have different expression patterns: CDY1 transcripts have the best correlation with complete spermatogenesis". Human Genetics. 113 (6): 486–492. doi:10.1007/s00439-003-0990-9. PMID 14569460. S2CID 43221279.
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