CEBPD
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Template:Cs1 config Template:Short description An Error has occurred retrieving Wikidata item for infobox CCAAT/enhancer-binding protein delta is a protein that in humans is encoded by the CEBPD gene.[1][2]
Function
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages.[3]
Functions
CEBPD is involved in regulation of apoptosis and cell proliferation. It probably acts as tumor suppressor.[4]
One study in mice showed that CEBPD prevents development of tubular injury and tubulointerstitial fibrogenesis during the progression of chronic obstructive nephropathy.[5]
Function of CEBPD gene can be effectively examined by siRNA knockdown based on an independent validation.[6]
Interactions
CEBPD has been shown to interact with Mothers against decapentaplegic homolog 3.[7]
See also
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Cao Z, Umek RM, McKnight SL (September 1991). "Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells". Genes & Development. 5 (9): 1538–1552. doi:10.1101/gad.5.9.1538. PMID 1840554.
- ^ Page Module:Citation/CS1/styles.css has no content.Williams SC, Cantwell CA, Johnson PF (September 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development. 5 (9): 1553–1567. doi:10.1101/gad.5.9.1553. PMID 1884998.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CEBPD CCAAT/enhancer binding protein (C/EBP), delta".
- ^ Page Module:Citation/CS1/styles.css has no content.Gery S, Tanosaki S, Hofmann WK, Koppel A, Koeffler HP (February 2005). "C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation". Oncogene. 24 (9): 1589–1597. doi:10.1038/sj.onc.1208393. PMID 15674331. S2CID 24347537.
- ^ Page Module:Citation/CS1/styles.css has no content.Duitman J, Borensztajn KS, Pulskens WP, Leemans JC, Florquin S, Spek CA (January 2014). "CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy". Laboratory Investigation; A Journal of Technical Methods and Pathology. 94 (1): 89–97. doi:10.1038/labinvest.2013.127. PMID 24247561.
- ^ Page Module:Citation/CS1/styles.css has no content.Munkácsy G, Sztupinszki Z, Herman P, Bán B, Pénzváltó Z, Szarvas N, et al. (September 2016). "Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments". Molecular Therapy. Nucleic Acids. 5 (9) e366. doi:10.1038/mtna.2016.66. PMC 5056990. PMID 27673562.
- ^ Page Module:Citation/CS1/styles.css has no content.Choy L, Derynck R (March 2003). "Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function". The Journal of Biological Chemistry. 278 (11): 9609–9619. doi:10.1074/jbc.M212259200. PMID 12524424.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Sladek FM, Darnell JE (April 1992). "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development. 2 (2): 256–259. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
- Page Module:Citation/CS1/styles.css has no content.Kinoshita S, Akira S, Kishimoto T (February 1992). "A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6". Proceedings of the National Academy of Sciences of the United States of America. 89 (4): 1473–1476. Bibcode:1992PNAS...89.1473K. doi:10.1073/pnas.89.4.1473. PMC 48473. PMID 1741402.
- Page Module:Citation/CS1/styles.css has no content.Nagulapalli S, Pongubala JM, Atchison ML (November 1995). "Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)". Journal of Immunology. 155 (9): 4330–4338. doi:10.4049/jimmunol.155.9.4330. PMID 7594592.
- Page Module:Citation/CS1/styles.css has no content.Wood S, Schertzer M, Yaremko ML (1995). "Sequence identity locates CEBPD and FGFR1 to mapped human loci within proximal 8p". Cytogenetics and Cell Genetics. 70 (3–4): 188–191. doi:10.1159/000134030. PMID 7789168.
- Page Module:Citation/CS1/styles.css has no content.Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, et al. (May 1993). "The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization". Genomics. 16 (2): 520–523. doi:10.1006/geno.1993.1220. PMID 8314590.
- Page Module:Citation/CS1/styles.css has no content.Chen PL, Riley DJ, Chen Y, Lee WH (November 1996). "Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs". Genes & Development. 10 (21): 2794–2804. doi:10.1101/gad.10.21.2794. PMID 8946919.
- Page Module:Citation/CS1/styles.css has no content.Xia C, Cheshire JK, Patel H, Woo P (December 1997). "Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes". The International Journal of Biochemistry & Cell Biology. 29 (12): 1525–1539. doi:10.1016/S1357-2725(97)00083-6. PMID 9570146.
- Page Module:Citation/CS1/styles.css has no content.Zhu Y, Saunders MA, Yeh H, Deng WG, Wu KK (March 2002). "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins". The Journal of Biological Chemistry. 277 (9): 6923–6928. doi:10.1074/jbc.M108075200. PMID 11741938.
- Page Module:Citation/CS1/styles.css has no content.Angeloni D, Lee JD, Johnson BE, Teh BT, Dean M, Lerman MI, et al. (December 2001). "C306A single nucleotide polymorphism in the human CEBPD gene that maps at 8p11.1-p11.2". Molecular and Cellular Probes. 15 (6): 395–397. doi:10.1006/mcpr.2001.0377. hdl:11382/3170. PMID 11851384. S2CID 8215328.
- Page Module:Citation/CS1/styles.css has no content.Gao H, Parkin S, Johnson PF, Schwartz RC (October 2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters". The Journal of Biological Chemistry. 277 (41): 38827–38837. doi:10.1074/jbc.M206224200. PMID 12177065.
- Page Module:Citation/CS1/styles.css has no content.Dearth LR, DeWille J (March 2003). "Posttranscriptional and posttranslational regulation of C/EBP delta in G0 growth-arrested mammary epithelial cells". The Journal of Biological Chemistry. 278 (13): 11246–11255. doi:10.1074/jbc.M207930200. PMID 12554732.
- Page Module:Citation/CS1/styles.css has no content.Milde-Langosch K, Löning T, Bamberger AM (May 2003). "Expression of the CCAAT/enhancer-binding proteins C/EBPalpha, C/EBPbeta and C/EBPdelta in breast cancer: correlations with clinicopathologic parameters and cell-cycle regulatory proteins". Breast Cancer Research and Treatment. 79 (2): 175–185. doi:10.1023/A:1023929504884. PMID 12825852. S2CID 45020949.
- Page Module:Citation/CS1/styles.css has no content.Kovács KA, Steinmann M, Magistretti PJ, Halfon O, Cardinaux JR (September 2003). "CCAAT/enhancer-binding protein family members recruit the coactivator CREB-binding protein and trigger its phosphorylation". The Journal of Biological Chemistry. 278 (38): 36959–36965. doi:10.1074/jbc.M303147200. PMID 12857754.
- Page Module:Citation/CS1/styles.css has no content.Chen YW, Hubal MJ, Hoffman EP, Thompson PD, Clarkson PM (December 2003). "Molecular responses of human muscle to eccentric exercise". Journal of Applied Physiology. 95 (6): 2485–2494. doi:10.1152/japplphysiol.01161.2002. PMID 12937035. S2CID 9817319.
- Page Module:Citation/CS1/styles.css has no content.Li R, Strohmeyer R, Liang Z, Lue LF, Rogers J (September 2004). "CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease". Neurobiology of Aging. 25 (8): 991–999. doi:10.1016/j.neurobiolaging.2003.10.016. PMID 15212823. S2CID 54232508.
- Page Module:Citation/CS1/styles.css has no content.Sivko GS, Sanford DC, Dearth LD, Tang D, DeWille JW (November 2004). "CCAAT/Enhancer binding protein delta (c/EBPdelta) regulation and expression in human mammary epithelial cells: II. Analysis of activating signal transduction pathways, transcriptional, post-transcriptional, and post-translational control". Journal of Cellular Biochemistry. 93 (4): 844–856. doi:10.1002/jcb.20224. PMID 15389878. S2CID 31572695.
External links
- Template:UCSC gene info
- CEBPD+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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