CPLX1
From Wikipedia, the free encyclopedia
Template:Short description An Error has occurred retrieving Wikidata item for infobox Complexin-1 is a protein that in humans is encoded by the CPLX1 gene.[1][2]
Function
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.[2]
Interactions
CPLX1 has been shown to interact with SNAP-25[3][4] and STX1A.[5][3][4]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.McMahon HT, Missler M, Li C, Südhof TC (Oct 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862. S2CID 675343.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CPLX1 complexin 1".
- ^ a b Page Module:Citation/CS1/styles.css has no content.Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J (Jan 2002). "Three-dimensional structure of the complexin/SNARE complex". Neuron. 33 (3): 397–409. doi:10.1016/S0896-6273(02)00583-4. PMID 11832227. S2CID 17878965.
- ^ a b Page Module:Citation/CS1/styles.css has no content.Hu K, Carroll J, Rickman C, Davletov B (Nov 2002). "Action of complexin on SNARE complex". The Journal of Biological Chemistry. 277 (44): 41652–6. doi:10.1074/jbc.M205044200. PMID 12200427.
- ^ Page Module:Citation/CS1/styles.css has no content.Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J (Aug 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". The EMBO Journal. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.
External links
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Abe T (Jun 2002). "[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis]". Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 47 (7): 794–800. PMID 12058476.
- Page Module:Citation/CS1/styles.css has no content.Ishizuka T, Saisu H, Odani S, Abe T (Aug 1995). "Synaphin: a protein associated with the docking/fusion complex in presynaptic terminals". Biochemical and Biophysical Research Communications. 213 (3): 1107–14. doi:10.1006/bbrc.1995.2241. PMID 7654227.
- Page Module:Citation/CS1/styles.css has no content.Harrison PJ, Eastwood SL (Nov 1998). "Preferential involvement of excitatory neurons in medial temporal lobe in schizophrenia". Lancet. 352 (9141): 1669–73. doi:10.1016/S0140-6736(98)03341-8. PMID 9853440. S2CID 45239545.
- Page Module:Citation/CS1/styles.css has no content.Ishizuka T, Saisu H, Odani S, Kumanishi T, Abe T (Jan 1999). "Distinct regional distribution in the brain of messenger RNAs for the two isoforms of synaphin associated with the docking/fusion complex". Neuroscience. 88 (1): 295–306. doi:10.1016/S0306-4522(98)00223-1. PMID 10051208. S2CID 46636775.
- Page Module:Citation/CS1/styles.css has no content.Eastwood SL, Cotter D, Harrison PJ (2001). "Cerebellar synaptic protein expression in schizophrenia". Neuroscience. 105 (1): 219–29. doi:10.1016/S0306-4522(01)00141-5. PMID 11483314. S2CID 34257327.
- Page Module:Citation/CS1/styles.css has no content.Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J (Jan 2002). "Three-dimensional structure of the complexin/SNARE complex". Neuron. 33 (3): 397–409. doi:10.1016/S0896-6273(02)00583-4. PMID 11832227. S2CID 17878965.
- Page Module:Citation/CS1/styles.css has no content.Sawada K, Young CE, Barr AM, Longworth K, Takahashi S, Arango V, Mann JJ, Dwork AJ, Falkai P, Phillips AG, Honer WG (2002). "Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness". Molecular Psychiatry. 7 (5): 484–92. doi:10.1038/sj.mp.4000978. PMID 12082566.
- Page Module:Citation/CS1/styles.css has no content.Basso M, Giraudo S, Corpillo D, Bergamasco B, Lopiano L, Fasano M (Dec 2004). "Proteome analysis of human substantia nigra in Parkinson's disease". Proteomics. 4 (12): 3943–52. doi:10.1002/pmic.200400848. hdl:11383/1491905. PMID 15526345. S2CID 23119746.
- Page Module:Citation/CS1/styles.css has no content.Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Page Module:Citation/CS1/styles.css has no content.Giraudo CG, Eng WS, Melia TJ, Rothman JE (Aug 2006). "A clamping mechanism involved in SNARE-dependent exocytosis". Science. 313 (5787): 676–80. Bibcode:2006Sci...313..676G. doi:10.1126/science.1129450. PMID 16794037. S2CID 28309295.
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