CRLF2
Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Cytokine receptor-like factor 2 (also known as TSLP receptor, TSLP-R) is a protein that in humans is encoded by the CRLF2 gene. It forms a ternary signaling complex with TSLP and interleukin-7 receptor-α, capable of stimulating cell proliferation through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) (chromosome 14), or with P2Y purinoceptor 8 gene (P2RY8) (chromosome X or Y) is associated with B-progenitor- and Down syndrome- acute lymphoblastic leukemia (ALL).[1][2][3]
Cytokine signals are mediated through specific receptor complexes, the components of which are mostly members of the type I cytokine receptor family. Type I cytokine receptors share conserved structural features in their extracellular domain. Receptor complexes are typically heterodimeric, consisting of alpha chains, which provide ligand specificity, and beta (or gamma) chains, which are required for the formation of high-affinity binding sites and signal transduction.[3]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, et al. (March 2001). "Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes". Biochemical and Biophysical Research Communications. 281 (4): 878–883. Bibcode:2001BBRC..281..878Z. doi:10.1006/bbrc.2001.4432. PMID 11237741.
- ^ Page Module:Citation/CS1/styles.css has no content.Tonozuka Y, Fujio K, Sugiyama T, Nosaka T, Hirai M, Kitamura T (Jul 2001). "Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR". Cytogenetics and Cell Genetics. 93 (1–2): 23–25. doi:10.1159/000056941. PMID 11474172. S2CID 83630087.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CRLF2 cytokine receptor-like factor 2".
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Page Module:Citation/CS1/styles.css has no content.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Page Module:Citation/CS1/styles.css has no content.Hiroyama T, Iwama A, Morita Y, Nakamura Y, Shibuya A, Nakauchi H (May 2000). "Molecular cloning and characterization of CRLM-2, a novel type I cytokine receptor preferentially expressed in hematopoietic cells". Biochemical and Biophysical Research Communications. 272 (1): 224–229. Bibcode:2000BBRC..272..224H. doi:10.1006/bbrc.2000.2764. hdl:2241/1571. PMID 10872831. S2CID 38299268.
- Page Module:Citation/CS1/styles.css has no content.Reche PA, Soumelis V, Gorman DM, Clifford T, Travis M, Zurawski SM, et al. (July 2001). "Human thymic stromal lymphopoietin preferentially stimulates myeloid cells". Journal of Immunology. 167 (1): 336–343. doi:10.4049/jimmunol.167.1.336. PMID 11418668.
- Page Module:Citation/CS1/styles.css has no content.Blagoev B, Nielsen MM, Angrist M, Chakravarti A, Pandey A (February 2002). "Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene". Gene. 284 (1–2): 161–168. doi:10.1016/S0378-1119(02)00380-3. PMID 11891057.
- Page Module:Citation/CS1/styles.css has no content.Rochman I, Watanabe N, Arima K, Liu YJ, Leonard WJ (June 2007). "Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells". Journal of Immunology. 178 (11): 6720–6724. doi:10.4049/jimmunol.178.11.6720. PMID 17513717.
