CSTF1

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Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.[1][2][3]

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3' end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene.[3]

Interactions

CSTF1 has been shown to interact with BARD1.[2][4]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Takagaki Y, Manley JL (November 1992). "A human polyadenylation factor is a G protein beta-subunit homologue". The Journal of Biological Chemistry. 267 (33): 23471–4. doi:10.1016/S0021-9258(18)35861-7. PMID 1358884.
  2. ^ a b Page Module:Citation/CS1/styles.css has no content.Kleiman FE, Manley JL (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53. doi:10.1016/S0092-8674(01)00270-7. PMID 11257228. S2CID 15022237.
  3. ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa".
  4. ^ Page Module:Citation/CS1/styles.css has no content.Kleiman FE, Manley JL (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433): 1576–9. doi:10.1126/science.285.5433.1576. PMID 10477523.

Further reading

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