Carbarsone

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Carbarsone
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Names
Preferred IUPAC name
[4-(Carbamoylamino)phenyl]arsonic acid
Other names
(4-Ureidophenyl)arsonic acid
Identifiers
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3D model (JSmol)
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MeSH Carbarson
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  • InChI=1S/C7H9AsN2O4/c9-7(11)10-6-3-1-5(2-4-6)8(12,13)14/h1-4H,(H3,9,10,11)(H2,12,13,14) checkY
    Key: WWXBHTZSYYGCSG-UHFFFAOYSA-N checkY
  • InChI=1/C7H9AsN2O4/c9-7(11)10-6-3-1-5(2-4-6)8(12,13)14/h1-4H,(H3,9,10,11)(H2,12,13,14)
    Key: WWXBHTZSYYGCSG-UHFFFAOYAW
  • O=C(Nc1ccc(cc1)[As](=O)(O)O)N
  • NC(=O)NC1=CC=C(C=C1)[As](O)(O)=O
Properties
C7H9AsN2O4
Molar mass 260.081 g·mol−1
Pharmacology
Oral
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Template:Chembox Footer/trackingTemplate:Short description

Carbarsone is an organoarsenic compound used as an antiprotozoal drug for treatment of amebiasis and other infections.[1][2][3] It was available for amebiasis in the United States as late as 1991. Thereafter, it remained available as a turkey feed additive for increasing weight gain and controlling histomoniasis (blackhead disease).[4][5]

Carbarsone is one of four arsenical animal drugs approved by the U.S. Food and Drug Administration for use in poultry and/or swine, along with nitarsone, arsanilic acid, and roxarsone.[6] In September 2013, the FDA announced that Zoetis and Fleming Laboratories would voluntarily withdraw current roxarsone, arsanilic acid, and carbarsone approvals, leaving only nitarsone approvals in place.[7] In 2015 FDA withdrew the approval of using nitarsone in animal feeds. The ban came into effect at the end of 2015.[8]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.SASAKI T, YOKAGAWA M, WYKOFF DE, RITICHIE LS (1956). "Asymptomatic amebiasis; treatment with atabrine in combination with carbarsone or chiniofon". United States Armed Forces Medical Journal. 7 (3): 363–8. PMID 13299463.
  2. ^ Page Module:Citation/CS1/styles.css has no content.RADKE RA (1955). "Ameboma of the intestine: an analysis of the disease as presented in 78 collected and 41 previously unreported cases". Ann. Intern. Med. 43 (5): 1048–66. doi:10.7326/0003-4819-43-5-1048. PMID 13268997.
  3. ^ Page Module:Citation/CS1/styles.css has no content.HOEKENGA MT (1 July 1951). "A comparison of aureomycin and carbarsone in the treatment of intestinal amebiasis". Am. J. Trop. Med. Hyg. 31 (4): 423–5. doi:10.4269/ajtmh.1951.s1-31.423. PMID 14857246.
  4. ^ Page Module:Citation/CS1/styles.css has no content.McDougald LR (1979). "Efficacy and compatibility of amprolium and carbarsone against Coccidiosis and blackhead in turkeys". Poult. Sci. 58 (1): 76–80. doi:10.3382/ps.0580076. PMID 572970.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Worden AN, Wood EC (1973). "The effect of Carbarsone (33.6 per cent w-v p-ureidobenzene arsonic acid) on bodyweight gain, food conversion and tissue arsenic levels of turkey poults". J. Sci. Food Agric. 24 (1): 35–41. doi:10.1002/jsfa.2740240107. PMID 4696593.
  6. ^ Page Module:Citation/CS1/styles.css has no content.U.S. Food and Drug Administration (June 8, 2011). "Questions and Answers Regarding 3-Nitro (Roxarsone)". Archived from the original on June 12, 2011.
  7. ^ Page Module:Citation/CS1/styles.css has no content.U.S. Food and Drug Administration (September 20, 2011). "FDA Response to Citizen Petition on Arsenic-based Animal Drugs". Archived from the original on October 22, 2013.
  8. ^ Page Module:Citation/CS1/styles.css has no content.U.S. Food and Drug Administration (April 1, 2015). "FDA Announces Pending Withdrawal of Approval of Nitarsone". Archived from the original on April 4, 2015.

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