Cefalotin

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Cefalotin
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Clinical data
AHFS/Drugs.comInternational Drug Names
MedlinePlusa682860
Pregnancy
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  • AU: A
Routes of
administration		Intravenous
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Legal status
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Pharmacokinetic data
Bioavailabilityn/a
Protein binding65 to 80%
MetabolismHepatic
Elimination half-life30 minutes to 1 hour
ExcretionRenal
Identifiers
  • (6R,7R)-3-[(acetoxy)methyl]-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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Chemical and physical data
FormulaC16H16N2O6S2
Molar mass396.43 g·mol−1
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Melting point160 to 160.5 °C (320.0 to 320.9 °F)
  • O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)Cc3sccc3)COC(=O)C)C(=O)O
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Cefalotin (INN) /ˌsɛfəˈloʊtɪn/ or cephalothin (USAN) /ˌsɛfəˈloʊθɪn/ is a first-generation cephalosporin antibiotic with broad spectrum antibiotic activity.[1][2] It was the first cephalosporin marketed (1964) and continues to be widely used.[3] Cefalotin is used for bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, bones and joints, sepsis, peritonitis, osteomyelitis, mastitis, infected wounds, and post-operational infections.[2]

It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agents cefalexin and cefadroxil. Cefalotin sodium is marketed as Keflin (Lilly) and under other trade names.[4]

The compound is a derivative of thiophene-2-acetic acid.[5]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Hameed TK, Robinson JL (July 2002). "Review of the use of cephalosporins in children with anaphylactic reactions from penicillins". The Canadian Journal of Infectious Diseases. 13 (4): 253–8. doi:10.1155/2002/712594. PMC 2094874. PMID 18159398.
  2. ^ a b Page Module:Citation/CS1/styles.css has no content.Vardanyan R, Hruby V (2006). "Antibiotics". Synthesis of Essential Drugs. pp. 425–498. doi:10.1016/B978-044452166-8/50032-7. ISBN 978-0-444-52166-8.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Greenwood D (21 February 2008). Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph. OUP Oxford. pp. 128–. ISBN 978-0-19-953484-5.
  4. ^ International Drug Names: Cefalotin
  5. ^ Page Module:Citation/CS1/styles.css has no content.Swanston J (2006). "Thiophene". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a26_793.pub2. ISBN 3527306730..

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