Cephem
From Wikipedia, the free encyclopedia
Cephems are a sub-group of β-lactam antibiotics including cephalosporins and cephamycins.[1] It is one of the more common 4-membered ring Heterocyclic compounds in the clinic.[2] Produced by actinomycetes, cephamycins were found to display antibacterial activity against a wide range of bacteria, including those resistant to penicillin and cephalosporins.[3] The antimicrobial properties of cephem include the attachment to certain penicillin-binding proteins that are involved in the production of cell walls of bacteria.[4]
Further reading
- Page Module:Citation/CS1/styles.css has no content.Hamilton-Miller JM (November 2003). "Chemical and microbiologic aspects of penems, a distinct class of beta-lactams: focus on faropenem". Pharmacotherapy. 23 (11): 1497–1507. doi:10.1592/phco.23.14.1497.31937. PMID 14620395. S2CID 43705118.
- Page Module:Citation/CS1/styles.css has no content.Ito K, Hayasaki M, Tamaya T (June 1990). "Pharmacokinetics of cephem antibiotics in exudate of pelvic retroperitoneal space after radical hysterectomy and pelvic lymphadenectomy". Antimicrobial Agents and Chemotherapy. 34 (6): 1160–1164. doi:10.1128/AAC.34.6.1160. PMC 171777. PMID 2393276.
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Bryskier, André (2000). "Cephems. Fifty Years of Continuous Research". The Journal of Antibiotics. 53 (10): 1028–1037. doi:10.7164/antibiotics.53.1028. PMID 11132947.
- ^ Page Module:Citation/CS1/styles.css has no content.Vitaku E, Smith DT, Njardarson JT (December 2014). "Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals". Journal of Medicinal Chemistry. 57 (24): 10257–10274. doi:10.1021/jm501100b. PMID 25255204.
- ^ Page Module:Citation/CS1/styles.css has no content.Stapley EO, Jackson M, Hernandez S, Zimmerman SB, Currie SA, Mochales S, et al. (September 1972). "Cephamycins, a new family of beta-lactam antibiotics. I. Production by actinomycetes, including Streptomyces lactamdurans sp. n". Antimicrobial Agents and Chemotherapy. 2 (3): 122–131. doi:10.1128/AAC.2.3.122. PMC 444278. PMID 4790552.
- ^ Page Module:Citation/CS1/styles.css has no content.Molteni E, Onida G, Ceccarelli M, Cappellini G (2021-04-03). "Ab Initio Spectroscopic Investigation of Pharmacologically Relevant Chiral Molecules: The Cases of Avibactam, Cephems, and Idelalisib as Benchmarks for Antibiotics and Anticancer Drugs". Symmetry. 13 (4): 601. Bibcode:2021Symm...13..601M. doi:10.3390/sym13040601. hdl:2434/831526. ISSN 2073-8994.
Further reading
- Page Module:Citation/CS1/styles.css has no content.Bryskier, André (2000). "Cephems. Fifty Years of Continuous Research". The Journal of Antibiotics. 53 (10): 1028–1037. doi:10.7164/antibiotics.53.1028. PMID 11132947.
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