Clofibride

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Clofibride
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Clinical data
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Pharmacokinetic data
MetabolismHydrolyzed to clofibric acid; hepatic glucuronidation
Elimination half-life12 hours (clofibric acid)
ExcretionRenal (mostly) and fecal
Identifiers
  • 3-(dimethylcarbamoyl)propyl 2-(4-chlorophenoxy)-2-methylpropanoate
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Chemical and physical data
FormulaC16H22ClNO4
Molar mass327.81 g·mol−1
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  • Clc1ccc(OC(C(=O)OCCCC(=O)N(C)C)(C)C)cc1
  • InChI=1S/C16H22ClNO4/c1-16(2,22-13-9-7-12(17)8-10-13)15(20)21-11-5-6-14(19)18(3)4/h7-10H,5-6,11H2,1-4H3 checkY
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Clofibride is a fibrate. Clofibride is a derivative of clofibrate. In the body it is converted into 4-chlorophenoxyisobutyric acid (clofibric acid),[1] which is the true hypolipidemic agent.[2][3] So clofibride, just like clofibrate is a prodrug of clofibric acid.

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content."Clofibride".
  2. ^ Template:RömppOnline
  3. ^ Page Module:Citation/CS1/styles.css has no content.Romics L (November 1988). "[Basic principles of drug therapy of hyperlipoproteinemia]". Orvosi Hetilap (in Hungarian). 129 (45): 2391–2399. PMID 3054710.{{cite journal}}: CS1 maint: unrecognized language (link)

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