Clopamide

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Clopamide
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Clinical data
Trade namesBrinaldix
AHFS/Drugs.comInternational Drug Names
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Identifiers
  • 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-
    benzamide
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Chemical and physical data
FormulaC14H20ClN3O3S
Molar mass345.84 g·mol−1
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  • O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N
  • InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21) checkY
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Clopamide (trade name Brinaldix) is a piperidine diuretic.[1]

Mechanism of action

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.

References

  1. ^ Page Module:Citation/CS1/styles.css has no content.McNeil JJ, Conway EL, Drummer OH, Howes LG, Christophidis N, Louis WJ (September 1987). "Clopamide: plasma concentrations and diuretic effect in humans". Clinical Pharmacology and Therapeutics. 42 (3): 299–304. doi:10.1038/clpt.1987.151. PMID 3621784. S2CID 20000178.

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