Clopenthixol
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Clopenthixol (Sordinol), also known as clopentixol, is a typical antipsychotic drug of the thioxanthene class. It was introduced by Lundbeck in 1961.[1]
Clopenthixol is a mixture of cis and trans isomers. Zuclopenthixol, the pure cis isomer, was later introduced by Lundbeck in 1962,[2] and has been much more widely used. Both drugs are equally effective as antipsychotics and have similar adverse effect profiles, but clopenthixol is half as active on a milligram-to-milligram basis and appears to produce more sedation in comparison.[3]
Clopenthixol is not approved for use in the United States.
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References
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- ^ Page Module:Citation/CS1/styles.css has no content.Sneader W (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.
- ^ Page Module:Citation/CS1/styles.css has no content.Vela JM, Buschmann H, Holenz J, Párraga A, Torrens A (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 516. ISBN 978-3-527-31058-6.[permanent dead link]
- ^ Page Module:Citation/CS1/styles.css has no content.Gravem A, Engstrand E, Guleng RJ (November 1978). "Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation". Acta Psychiatrica Scandinavica. 58 (5): 384–388. doi:10.1111/j.1600-0447.1978.tb03570.x. PMID 362830. S2CID 44833311.
External links
- Clopenthixol at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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