Cmin
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Template:DMCA Cmin is a term used in pharmacokinetics for the minimum blood plasma concentration reached by a drug during a dosing interval, which is the time interval between administration of two doses. This definition is slightly different from Ctrough, the concentration immediately prior to administration of the next dose.[1] Cmin is the opposite of Cmax, the maximum concentration that the drug reaches. Cmin must be above certain thresholds, such as the minimum inhibitory concentration (MIC), to achieve a therapeutic effect.[2]
In most cases Cmin is directly measurable. At steady state the minimum plasma concentration can also be calculated using the following equation:[3]
- S = Salt factor
- F = Bioavailability
- D = Dose
- ke = Elimination rate constant
- ka = Absorption rate constant
- Vd = Volume of distribution
- τ = Dosing interval
Cmin is also an important parameter in bioavailability and bioequivalence studies, it is part of the pharmacokinetic information recommended for submission of investigational new drug applications.[4]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Weimann HJ, Cawello W, Brett M, Zimmermann H, Pabst G, Sierakowski B, et al. (1999). "Drug concentrations and directly derived parameters". Parameters for Compartment Free Pharmacokinetics: Standardisation of Study Design, Data Analysis and Reporting. Aachen, Germany: Shaker-Verlag. pp. 25–40. ISBN 978-3-8265-4767-6. OCLC 44511664. (pages 31–34 in 2003 edition)
- ^ Page Module:Citation/CS1/styles.css has no content.Dalton BR (February 2023). "What Is the Best Vancomycin Therapeutic Drug Monitoring Parameter to Assess Efficacy? A Critical Review of Experimental Data and Assessment of the Need for Individual Patient Minimum Inhibitory Concentration Value". Microorganisms. 11 (3): 567. doi:10.3390/microorganisms11030567. PMC 10051726. PMID 36985141.
- ^ Page Module:Citation/CS1/styles.css has no content.Dhillon S, Gill K (2006). "Basic pharmacokinetics". Clinical pharmacokinetics (PDF). Pharmaceutical Press. pp. 1–44. ISBN 9780853695714. Archived from the original (PDF) on 29 March 2018.
- ^ Page Module:Citation/CS1/styles.css has no content."Bioavailability and Bioequivalence, Studies for Orally Administered Drug Products — General Considerations" (PDF). Guidance for Industry. Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration. March 2003. Archived from the original (PDF) on 19 March 2013.
