Condensation domain
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| Condensation | |||||||
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| Identifiers | |||||||
| Symbol | Condensation | ||||||
| Pfam | PF00668 | ||||||
| Pfam clan | CL0149 | ||||||
| InterPro | IPR001242 | ||||||
| SCOP2 | 1l5a / SCOPe / SUPFAM | ||||||
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 | This article needs additional citations for verification. (May 2026) |
In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.[1]
References
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- ^ Page Module:Citation/CS1/styles.css has no content.Stachelhaus T, Mootz HD, Bergendahl V, Marahiel MA (August 1998). "Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain". J. Biol. Chem. 273 (35): 22773–81. doi:10.1074/jbc.273.35.22773. PMID 9712910.
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