ctRNA
In molecular biology ctRNA (counter-transcribed RNA) is a plasmid encoded noncoding RNA that binds to the mRNA of Template:Chem name and causes translational inhibition.[1] ctRNA is encoded by plasmids and functions in rolling circle replication to maintain a low copy number. In Corynebacterium glutamicum, it achieves this by antisense pairing with the mRNA of Template:Chem name, a replication initiation protein.[1] In Enterococcus faecium the plasmid pJB01 contains three open reading frames, copA, Template:Chem name, and Template:Chem name. The pJB01 ctRNA is coded on the opposite strand from the Template:Chem name/Template:Chem name intergenic region and partially overlaps an atypical ribosome binding site for Template:Chem name.[2]
See also
References
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- ^ a b Page Module:Citation/CS1/styles.css has no content.Venkova-Canova, T; Patek M; Nesvera J (2003). "Control of rep gene expression in plasmid pGA1 from Corynebacterium glutamicum". J Bacteriol. 185 (8): 2402–2409. doi:10.1128/JB.185.8.2402-2409.2003. PMC 152619. PMID 12670963.
- ^ Page Module:Citation/CS1/styles.css has no content.Kim SW, Jeong IS, Jeong EJ, et al. (July 2008). "The terminal and internal hairpin loops of the ctRNA of plasmid pJB01 play critical roles in regulating copy number". Mol. Cells. 26 (1): 26–33. PMID 18511887.
