DDB1
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Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox DNA damage-binding protein 1 is a protein that in humans is encoded by the DDB1 gene.[1][2][3]
Gene
The gene's position is on chromosome 11q12-q13.[4]
Protein
The DDB1 gene encodes the large subunit of DNA damage-binding protein, a heterodimer composed of a large and a small (DDB2) subunit. DDB1 contains 1140 amino acids, amounting to a mass of 127 kDa.[4]
Function
As its name suggests, DDB1 was initially implicated in the process of a specific type of DNA repair known as nucleotide excision repair. Since then, researchers have found that DDB1 primarily functions as a core component of the CUL4A- and CUL4B-based E3 ubiquitin ligase complexes. DDB1 serves as a bridge or adaptor protein which interacts with dozens of proteins known as DDB1 and CUL4-associated factors (DCAFs).[5] These DCAFs are often ubiquitin ligase substrates and regulate numerous essential processes in the cell including DNA repair (DDB2), DNA replication, chromatin remodeling (Cdt2) and more.
Interactions
DDB1 has been shown to interact with Transcription initiation protein SPT3 homolog,[6] GCN5L2,[7] DDB2,[8][9] CUL4A,[9] CUL4B[9] and P21.[10]
References
Page Template:Reflist/styles.css has no content.
- ^ Page Module:Citation/CS1/styles.css has no content.Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S (February 1996). "Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein". Genomics. 29 (1): 62–69. doi:10.1006/geno.1995.1215. PMID 8530102.
- ^ Page Module:Citation/CS1/styles.css has no content.Seki N, Hayashi A, Hattori A, Kozuma S, Sasaki M, Suzuki Y, et al. (January 2000). "cDNA cloning, tissue expression, and chromosomal assignment of a mouse gene, encoding a 127 kDa UV-damaged DNA binding protein which is defective in XPE cells". DNA Research. 6 (5): 319–322. doi:10.1093/dnares/6.5.319. PMID 10574459.
- ^ Page Module:Citation/CS1/styles.css has no content."Entrez Gene: DDB1 damage-specific DNA binding protein 1, 127kDa".
- ^ a b Page Module:Citation/CS1/styles.css has no content.Iovine B, Iannella ML, Bevilacqua MA (December 2011). "Damage-specific DNA binding protein 1 (DDB1): a protein with a wide range of functions". The International Journal of Biochemistry & Cell Biology. 43 (12). Elsevier: 1664–1667. doi:10.1016/j.biocel.2011.09.001. PMID 21959250.
- ^ Page Module:Citation/CS1/styles.css has no content.Lee J (2007). "DCAFs, the Missing Link of the CUL4-DDB1 Ubiquitin Ligase". Molecular Cell. 26 (6): 775–780. doi:10.1016/j.molcel.2007.06.001. PMID 17588513.
- ^ Page Module:Citation/CS1/styles.css has no content.Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, et al. (October 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–6795. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
- ^ Page Module:Citation/CS1/styles.css has no content.Huang J, Chen J (July 2008). "VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation". Oncogene. 27 (29): 4056–4064. doi:10.1038/onc.2008.44. PMID 18332868. S2CID 23628888.
- ^ Page Module:Citation/CS1/styles.css has no content.Bergametti F, Sitterlin D, Transy C (July 2002). "Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex". Journal of Virology. 76 (13): 6495–6501. doi:10.1128/JVI.76.13.6495-6501.2002. PMC 136256. PMID 12050362.
- ^ a b c Page Module:Citation/CS1/styles.css has no content.Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapić-Otrin V (July 2008). "The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A". Cancer Research. 68 (13): 5014–5022. doi:10.1158/0008-5472.CAN-07-6162. PMID 18593899.
- ^ Page Module:Citation/CS1/styles.css has no content.Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A (September 2008). "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex". Genes & Development. 22 (18): 2496–2506. doi:10.1101/gad.1676108. PMC 2546691. PMID 18794347.
Further reading
Page Template:Refbegin/styles.css has no content.
- Page Module:Citation/CS1/styles.css has no content.Chu G, Chang E (1988). "Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA". Science. 242 (4878): 564–567. Bibcode:1988Sci...242..564C. doi:10.1126/science.3175673. PMID 3175673.
- Page Module:Citation/CS1/styles.css has no content.Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein". Journal of Virology. 69 (2): 1107–1114. doi:10.1128/JVI.69.2.1107-1114.1995. PMC 188683. PMID 7815490.
- Page Module:Citation/CS1/styles.css has no content.Keeney S, Eker AP, Brody T, Vermeulen W, Bootsma D, Hoeijmakers JH, et al. (April 1994). "Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein". Proceedings of the National Academy of Sciences of the United States of America. 91 (9): 4053–4056. Bibcode:1994PNAS...91.4053K. doi:10.1073/pnas.91.9.4053. PMC 43721. PMID 8171034.
- Page Module:Citation/CS1/styles.css has no content.Keeney S, Chang GJ, Linn S (1993). "Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E." The Journal of Biological Chemistry. 268 (28): 21293–21300. doi:10.1016/S0021-9258(19)36923-6. PMID 8407967.
- Page Module:Citation/CS1/styles.css has no content.Hwang BJ, Liao JC, Chu G (1996). "Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells". Mutation Research. 362 (1): 105–117. doi:10.1016/0921-8777(95)00040-2. PMID 8538642.
- Page Module:Citation/CS1/styles.css has no content.Nichols AF, Ong P, Linn S (1996). "Mutations specific to the xeroderma pigmentosum group E Ddb- phenotype". The Journal of Biological Chemistry. 271 (40): 24317–24320. doi:10.1074/jbc.271.40.24317. PMID 8798680.
- Page Module:Citation/CS1/styles.css has no content.Liu W, Nichols AF, Graham JA, Dualan R, Abbas A, Linn S (July 2000). "Nuclear transport of human DDB protein induced by ultraviolet light". The Journal of Biological Chemistry. 275 (28): 21429–21434. doi:10.1074/jbc.M000961200. PMID 10777491.
- Page Module:Citation/CS1/styles.css has no content.Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, et al. (October 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–6795. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
- Page Module:Citation/CS1/styles.css has no content.Chen X, Zhang Y, Douglas L, Zhou P (2002). "UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation". The Journal of Biological Chemistry. 276 (51): 48175–48182. doi:10.1074/jbc.M106808200. PMID 11673459.
- Page Module:Citation/CS1/styles.css has no content.Rapić-Otrin V, McLenigan MP, Bisi DC, Gonzalez M, Levine AS (June 2002). "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation". Nucleic Acids Research. 30 (11): 2588–2598. doi:10.1093/nar/30.11.2588. PMC 117178. PMID 12034848.
- Page Module:Citation/CS1/styles.css has no content.Bergametti F, Sitterlin D, Transy C (2002). "Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex". Journal of Virology. 76 (13): 6495–6501. doi:10.1128/JVI.76.13.6495-6501.2002. PMC 136256. PMID 12050362.
- Page Module:Citation/CS1/styles.css has no content.Bontron S, Lin-Marq N, Strubin M (2002). "Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2". The Journal of Biological Chemistry. 277 (41): 38847–38854. doi:10.1074/jbc.M205722200. PMID 12151405.
- Page Module:Citation/CS1/styles.css has no content.Andrejeva J, Poole E, Young DF, Goodbourn S, Randall RE (November 2002). "The p127 subunit (DDB1) of the UV-DNA damage repair binding protein is essential for the targeted degradation of STAT1 by the V protein of the paramyxovirus simian virus 5". Journal of Virology. 76 (22): 11379–11386. doi:10.1128/JVI.76.22.11379-11386.2002. PMC 136798. PMID 12388698.
- Page Module:Citation/CS1/styles.css has no content.Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, Drapkin R, et al. (May 2003). "The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage". Cell. 113 (3): 357–367. doi:10.1016/S0092-8674(03)00316-7. PMID 12732143. S2CID 11639677.
- Page Module:Citation/CS1/styles.css has no content.Leupin O, Bontron S, Strubin M (2003). "Hepatitis B virus X protein and simian virus 5 V protein exhibit similar UV-DDB1 binding properties to mediate distinct activities". Journal of Virology. 77 (11): 6274–6283. doi:10.1128/JVI.77.11.6274-6283.2003. PMC 154990. PMID 12743284.
- Page Module:Citation/CS1/styles.css has no content.Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, et al. (February 2004). "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase". Science. 303 (5662): 1371–1374. Bibcode:2004Sci...303.1371W. doi:10.1126/science.1093549. PMID 14739464. S2CID 40501515.
- Page Module:Citation/CS1/styles.css has no content.Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
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