DMPX

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DMPX
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Clinical data
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  • None
Identifiers
  • 3,7-Dimethyl-1-(2-propyn-1-yl)-3,7-dihydro-1H-purine-2,6-dione
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Chemical and physical data
FormulaC10H10N4O2
Molar mass218.216 g·mol−1
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  • Cn2cnc(c2c1=O)n(C)c(=O)n1CC#C
  • InChI=1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3
  • Key:IORPOFJLSIHJOG-UHFFFAOYSA-N
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DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity for A2 adenosine receptors, in contrast to the A1 subtype receptors.[1] DMPX had 28 times and 15 times higher potency than caffeine in blocking, respectively, the peripheral and central effects of the adenosine agonist NECA. The locomotor stimulation caused by DMPX (ED50 10 μmol/kg) was similarly higher than caffeine.[1]

See also

References

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  1. ^ a b Page Module:Citation/CS1/styles.css has no content.Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW (1988). "3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs". Life Sciences. 43 (21): 1671–84. doi:10.1016/0024-3205(88)90478-x. PMID 3193854.

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