DUSP1

Template:Short description Template:Cs1 config An Error has occurred retrieving Wikidata item for infobox Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.

Function

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Interactions

DUSP1 has been shown to interact with MAPK14, MAPK1 and MAPK8.

Further reading

• Martell KJ, Angelotti T, Ullrich A (Feb 1998). "The "VH1-like" dual-specificity protein tyrosine phosphatases". Molecules and Cells. 8 (1): 2–11. doi:10.1016/S1016-8478(23)13385-1. PMID 9571625.
• Keyse SM (Apr 1998). "Protein phosphatases and the regulation of MAP kinase activity". Seminars in Cell & Developmental Biology. 9 (2): 143–52. doi:10.1006/scdb.1997.0219. PMID 9599409.
• Abraham SM, Clark AR (Dec 2006). "Dual-specificity phosphatase 1: a critical regulator of innate immune responses". Biochemical Society Transactions. 34 (Pt 6): 1018–23. doi:10.1042/BST0341018. PMID 17073741.
• Raingeaud J, Gupta S, Rogers JS, Dickens M, Han J, Ulevitch RJ, Davis RJ (Mar 1995). "Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine". The Journal of Biological Chemistry. 270 (13): 7420–6. doi:10.1074/jbc.270.13.7420. PMID 7535770.
• Kwak SP, Hakes DJ, Martell KJ, Dixon JE (Feb 1994). "Isolation and characterization of a human dual specificity protein-tyrosine phosphatase gene". The Journal of Biological Chemistry. 269 (5): 3596–604. doi:10.1016/S0021-9258(17)41905-3. PMID 8106404.
• Emslie EA, Jones TA, Sheer D, Keyse SM (May 1994). "The CL100 gene, which encodes a dual specificity (Tyr/Thr) MAP kinase phosphatase, is highly conserved and maps to human chromosome 5q34". Human Genetics. 93 (5): 513–6. doi:10.1007/BF00202814. PMID 8168826. S2CID 12590731.
• Sun H, Charles CH, Lau LF, Tonks NK (Nov 1993). "MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo". Cell. 75 (3): 487–93. doi:10.1016/0092-8674(93)90383-2. PMID 8221888. S2CID 29988777.
• Charles CH, Sun H, Lau LF, Tonks NK (Jun 1993). "The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 90 (11): 5292–6. Bibcode:1993PNAS...90.5292C. doi:10.1073/pnas.90.11.5292. PMC 46702. PMID 8389479.
• Alessi DR, Smythe C, Keyse SM (Jul 1993). "The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts". Oncogene. 8 (7): 2015–20. PMID 8390041.
• Brondello JM, Pouysségur J, McKenzie FR (Dec 1999). "Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation". Science. 286 (5449): 2514–7. doi:10.1126/science.286.5449.2514. PMID 10617468.
• Hutter D, Chen P, Barnes J, Liu Y (Nov 2000). "Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation". The Biochemical Journal. 352 (1): 155–63. doi:10.1042/0264-6021:3520155. PMC 1221442. PMID 11062068.
• Slack DN, Seternes OM, Gabrielsen M, Keyse SM (May 2001). "Distinct binding determinants for ERK2/p38alpha and JNK map kinases mediate catalytic activation and substrate selectivity of map kinase phosphatase-1". The Journal of Biological Chemistry. 276 (19): 16491–500. doi:10.1074/jbc.M010966200. PMID 11278799.
• Manzano RG, Montuenga LM, Dayton M, Dent P, Kinoshita I, Vicent S, Gardner GJ, Nguyen P, Choi YH, Trepel J, Auersperg N, Birrer MJ (Jun 2002). "CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential". Oncogene. 21 (28): 4435–47. doi:10.1038/sj.onc.1205542. hdl:10171/20183. PMID 12080474.
• Imasato A, Desbois-Mouthon C, Han J, Kai H, Cato AC, Akira S, Li JD (Dec 2002). "Inhibition of p38 MAPK by glucocorticoids via induction of MAPK phosphatase-1 enhances nontypeable Haemophilus influenzae-induced expression of toll-like receptor 2". The Journal of Biological Chemistry. 277 (49): 47444–50. doi:10.1074/jbc.M208140200. PMID 12356755.
• Lasa M, Abraham SM, Boucheron C, Saklatvala J, Clark AR (Nov 2002). "Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38". Molecular and Cellular Biology. 22 (22): 7802–11. doi:10.1128/MCB.22.22.7802-7811.2002. PMC 134716. PMID 12391149.
• Denkert C, Schmitt WD, Berger S, Reles A, Pest S, Siegert A, Lichtenegger W, Dietel M, Hauptmann S (Dec 2002). "Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma". International Journal of Cancer. 102 (5): 507–13. doi:10.1002/ijc.10746. PMID 12432554. S2CID 45750943.

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