DUSP10
Template:Short description Template:Cs1 configAn Error has occurred retrieving Wikidata item for infobox Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.[1][2][3]
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different isoforms have been found for this gene.[3]
Interactions
DUSP10 has been shown to interact with MAPK14[4][5][6] and MAPK8.[1]
References
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- ^ a b Page Module:Citation/CS1/styles.css has no content.Tanoue T, Moriguchi T, Nishida E (Aug 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J Biol Chem. 274 (28): 19949–56. doi:10.1074/jbc.274.28.19949. PMID 10391943.
- ^ Page Module:Citation/CS1/styles.css has no content.Theodosiou A, Smith A, Gillieron C, Arkinstall S, Ashworth A (Jan 2000). "MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases". Oncogene. 18 (50): 6981–8. doi:10.1038/sj.onc.1203185. PMID 10597297.
- ^ a b Page Module:Citation/CS1/styles.css has no content."Entrez Gene: DUSP10 dual specificity phosphatase 10".
- ^ Page Module:Citation/CS1/styles.css has no content.Tanoue T, Moriguchi T, Nishida E (Jul 1999). "Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5". J. Biol. Chem. 274 (28). UNITED STATES: 19949–56. doi:10.1074/jbc.274.28.19949. ISSN 0021-9258. PMID 10391943.
- ^ Page Module:Citation/CS1/styles.css has no content.Tanoue T, Yamamoto T, Maeda R, Nishida E (Jul 2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. 276 (28). United States: 26629–39. doi:10.1074/jbc.M101981200. ISSN 0021-9258. PMID 11359773.
- ^ Page Module:Citation/CS1/styles.css has no content.Tanoue T, Maeda R, Adachi M, Nishida E (Feb 2001). "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. 20 (3). England: 466–79. doi:10.1093/emboj/20.3.466. ISSN 0261-4189. PMC 133461. PMID 11157753.
Further reading
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- Page Module:Citation/CS1/styles.css has no content.Martell KJ, Angelotti T, Ullrich A (1998). "The "VH1-like" dual-specificity protein tyrosine phosphatases". Mol. Cells. 8 (1): 2–11. doi:10.1016/S1016-8478(23)13385-1. PMID 9571625.
- Page Module:Citation/CS1/styles.css has no content.Teng CH, Huang WN, Meng TC (2007). "Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress". J. Biol. Chem. 282 (39): 28395–407. doi:10.1074/jbc.M705142200. PMID 17681939.
- Page Module:Citation/CS1/styles.css has no content.Tao X, Tong L (2007). "Crystal structure of the MAP kinase binding domain and the catalytic domain of human MKP5". Protein Sci. 16 (5): 880–6. doi:10.1110/ps.062712807. PMC 2206639. PMID 17400920.
- Page Module:Citation/CS1/styles.css has no content.Nonn L, Duong D, Peehl DM (2007). "Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells". Carcinogenesis. 28 (6): 1188–96. doi:10.1093/carcin/bgl241. PMID 17151092.
- Page Module:Citation/CS1/styles.css has no content.Jeong DG, Yoon TS, Kim JH, et al. (2006). "Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase". J. Mol. Biol. 360 (5): 946–55. doi:10.1016/j.jmb.2006.05.059. PMID 16806267.
- Page Module:Citation/CS1/styles.css has no content.Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Page Module:Citation/CS1/styles.css has no content.Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Page Module:Citation/CS1/styles.css has no content.Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Page Module:Citation/CS1/styles.css has no content.Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Page Module:Citation/CS1/styles.css has no content.Tanoue T, Yamamoto T, Maeda R, Nishida E (2001). "A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs". J. Biol. Chem. 276 (28): 26629–39. doi:10.1074/jbc.M101981200. PMID 11359773.
- Page Module:Citation/CS1/styles.css has no content.Masuda K, Shima H, Kikuchi K, et al. (2000). "Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10". Cytogenet. Cell Genet. 90 (1–2): 71–4. doi:10.1159/000015666. PMID 11060451. S2CID 30344543.
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