Denopamine

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Denopamine
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Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth
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  • none
Legal status
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  • Rx-only (JP)
Identifiers
  • 4-[(1S)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol
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Chemical and physical data
FormulaC18H23NO4
Molar mass317.385 g·mol−1
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  • O(c1ccc(cc1OC)CCNC[C@@H](O)c2ccc(O)cc2)C
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Denopamine (INN) is a drug which acts as a β1 adrenergic receptor agonist.[1] It is used in the treatment of angina[2] and may also have potential uses in the treatment of congestive heart failure[3] and for clearing pulmonary edema.[4] It is marketed in Japan under the brand name Kalgut and available as tablets of 5 and 10 mg, and 5% fine granules.[5]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Ishide T (2002). "Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator". Current Medical Research and Opinion. 18 (7): 407–13. doi:10.1185/030079902125001119. PMID 12487507. S2CID 25048757.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, et al. (April 2006). "Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment". International Journal of Cardiology. 108 (2): 281–3. doi:10.1016/j.ijcard.2005.03.012. PMID 15913812.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S (September 1998). "Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart". Journal of the American College of Cardiology. 32 (3): 808–15. doi:10.1016/S0735-1097(98)00314-3. hdl:2433/181223. PMID 9741531.
  4. ^ Page Module:Citation/CS1/styles.css has no content.Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, et al. (February 2001). "Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs". Japanese Journal of Pharmacology. 85 (2): 161–6. doi:10.1254/jjp.85.161. PMID 11286398.
  5. ^ Page Module:Citation/CS1/styles.css has no content."Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information" (PDF) (in Japanese). Mitsubishi Tanabe Pharma Corporation. Retrieved 6 March 2016.{{cite web}}: CS1 maint: unrecognized language (link)

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