Dichlorophen

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Dichlorophen
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Clinical data
AHFS/Drugs.comInternational Drug Names
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Identifiers
  • 4-Chloro-2-[(5-chloro-2-hydroxyphenyl)methyl]phenol
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Chemical and physical data
FormulaC13H10Cl2O2
Molar mass269.12 g·mol−1
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Density1.5 g/cm3 g/cm3
Melting point177.5 °C (351.5 °F)
Solubility in water0.003 g/100 mL[1] mg/mL (20 °C)
  • C1=CC(=C(C=C1Cl)CC2=C(C=CC(=C2)Cl)O)O
  • InChI=1S/C13H10Cl2O2/c14-10-1-3-12(16)8(6-10)5-9-7-11(15)2-4-13(9)17/h1-4,6-7,16-17H,5H2 ☒N
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Dichlorophen is an anticestodal agent, fungicide, germicide, and antimicrobial agent.[2] It is used in combination with toluene for the removal of parasites such as ascarids, hookworms, and tapeworms from dogs and cats.[3] In 2025, dichlorophen was reported to function as a tubulin binding mitotic inhibitor.[4]

Safety and regulation

The LD50 (oral, mouse) is 3300 mg/kg.[5]

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Lide DR (1998). Handbook of Chemistry and Physics (87 ed.). Boca Raton, Florida: CRC Press. pp. 8–118. ISBN 0-8493-0594-2.
  2. ^ Milne, G.W.A. (Ed.). (2005). Gardner's commercially important chemicals: Synonyms, trade names, and properties. Hoboken, N.J.: Wiley-Interscience. Google Books
  3. ^ Page Module:Citation/CS1/styles.css has no content."Code of Federal Regulations", Code of Federal Regulations, Title 21, Volume 6, U.S. Government Printing Office, 2005-04-01, retrieved 2009-05-01
  4. ^ Page Module:Citation/CS1/styles.css has no content.Baksheeva VE, La Rocca R, Allegro D, Derviaux C, Pasquier E, Roche P, Morelli X, Devred F, Golovin AV, Tsvetkov PO (2025). "NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights". Journal of Medicinal Chemistry. doi:10.1021/acs.jmedchem.5c01008.
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