Dimetacrine

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Dimetacrine
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Clinical data
Trade namesIstonil, Istonyl, Linostil, Miroistonil
Other namesDimethacrine, acripramine
Routes of
administration		Oral
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Legal status
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Identifiers
  • 3-(9,9-Dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine
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Chemical and physical data
FormulaC20H26N2
Molar mass294.442 g·mol−1
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  • CC1(C2=CC=CC=C2N(C3=CC=CC=C31)CCCN(C)C)C
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Dimetacrine (also known as dimethacrine and acripramine; brand names Istonil, Istonyl, Linostil, and Miroistonil) is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression.[2][3][4][5][6] It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.[7][8]

Little is known about the pharmacology of dimetacrine,[9] but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).

See also

References

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  1. ^ Page Module:Citation/CS1/styles.css has no content.Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in português do Brasil). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Page Module:Citation/CS1/styles.css has no content.Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
  3. ^ Page Module:Citation/CS1/styles.css has no content.Kato S (1993). "A Review of the Pharmacotherapy of Depression in Japan". In Kariya T, Nakagawara M (eds.). Affective Disorders: Perspective on Basic Research and Clinical Practice. Tokyo: Seiwa Shoten. ISBN 978-0-87630-674-1.
  4. ^ Page Module:Citation/CS1/styles.css has no content.Vela JM, Buschmann H, Holenz J, Párraga A, Torrens A (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. ISBN 978-3-527-31058-6.
  5. ^ Page Module:Citation/CS1/styles.css has no content.Taen S, Pöldinger W (December 1966). "[Dimethacrine (istonil), an acridane derivative with the antidepressive action]". Schweizerische Medizinische Wochenschrift (in Deutsch). 96 (48): 1616–1620. PMID 6008540.
  6. ^ Page Module:Citation/CS1/styles.css has no content.Meyer R (May 1968). "[Contribution to the clinical evaluation of the antidepressive effect of dimethacrine (Istonil)]". Praxis (in Deutsch). 57 (20): 721–723. PMID 5756370.
  7. ^ Page Module:Citation/CS1/styles.css has no content.Abuzzahab FS (November 1973). "A double-blind investigation of dimethacrine versus imipramine in hospitalized depressive states". International Journal of Clinical Pharmacology, Therapy and Toxicology. 8 (3): 244–253. PMID 4149236.
  8. ^ Page Module:Citation/CS1/styles.css has no content.Mutschler E, Derendorf H (1995). "Psychoactive Drugs: Antidepresants". Drug actions: basic principles and therapeutic aspects. Stuttgart, Germany: Medpharm Scientific Pub. ISBN 0-8493-7774-9. Retrieved January 30, 2013.
  9. ^ Page Module:Citation/CS1/styles.css has no content."Dimetacrine". PubChem. U.S. National Library of Medicine. Retrieved 2023-11-03.

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